Hydrocortisone (Corbal 100) 100mg Powder for Injection I.M/I.V Vial 10's

100mg Powder for Injection

CORTICOSTEROID

Product Description:

Hydrocortisone (Corbal 100) 100mg Powder for Injection is a corticosteroid used to treat a variety of conditions, including inflammation, severe allergies, autoimmune diseases, and certain types of cancer. It is available as a powder for reconstitution into a solution for injection, intended for intramuscular (IM) or intravenous (IV) administration. Hydrocortisone is a synthetic version of the naturally occurring hormone cortisol and works by reducing inflammation, suppressing the immune system, and affecting various metabolic processes in the body.

Each vial contains 100 mg of Hydrocortisone as the active ingredient, and it is used for acute management of severe conditions requiring potent anti-inflammatory and immunosuppressive effects.

Indications:

Hydrocortisone (Corbal 100) 100mg Powder for Injection is indicated for:

1. Acute Inflammatory Conditions:

   • Severe allergic reactions (e.g., anaphylaxis, angioedema).

   • Asthma or chronic obstructive pulmonary disease (COPD) exacerbations.

   • Rheumatic disorders (e.g., arthritis, bursitis).

   • Acute gouty arthritis.

   • Inflammatory skin conditions like dermatitis or eczema.

2. Autoimmune Diseases:

   • Systemic lupus erythematosus (SLE).

   • Rheumatoid arthritis.

   • Vasculitis and other autoimmune conditions.

3. Endocrine Disorders:

   • Adrenal insufficiency (e.g., Addison’s disease).

   • Congenital adrenal hyperplasia.

4. Cancer and Chemotherapy Support:

   • Treatment of certain types of cancer (e.g., leukemia, lymphoma) in combination with other medications.

5. Severe Infections (as adjunctive therapy to treat inflammation caused by infections).

Dosage and Administration:

Hydrocortisone (Corbal 100) 100mg Powder for Injection is administered by intravenous (IV) or intramuscular (IM) injection. The dosage depends on the severity of the condition being treated and the patient's response to treatment.

For Acute Inflammatory Conditions:

• Initial Dose:

  • 100 mg to 200 mg (IV/IM) every 4 to 6 hours until symptoms are controlled. The dose can be adjusted depending on the patient's response.

For Chronic Conditions (e.g., Rheumatoid Arthritis, SLE):

• Initial Dose:

  • 100 mg to 150 mg (IV/IM) once a day for 2 to 3 days.

  • Maintenance doses may be lower, depending on clinical response.

For Adrenal Insufficiency:

• Initial Dose:

  • 100 mg to 200 mg IV/IM for the initial treatment phase.

  • After stabilization, transition to oral hydrocortisone or other corticosteroids for long-term management.

Side Effects:

Hydrocortisone can cause a range of side effects, some of which can be serious:

Common Side Effects:

1. Gastrointestinal:

   • Nausea, vomiting, or upset stomach.

   • Peptic ulcers (with long-term use).

2. Fluid Retention:

   • Edema (swelling), weight gain.

3. Skin:

   • Thinning of skin, bruising, or delayed wound healing.

4. Metabolic:

   • Hyperglycemia (high blood sugar), fluid retention, electrolyte imbalances.

5. CNS:

   • Mood changes, insomnia, euphoria, or irritability.

Serious Side Effects:

1. Increased Risk of Infection:

   • Suppression of the immune system may increase the risk of infections.

2. Osteoporosis (with long-term use).

3. Cushing’s Syndrome:

   • Symptoms may include moon face, buffalo hump, and thin limbs.

4. Hypertension (high blood pressure).

5. Peptic Ulcers or Gastrointestinal Bleeding.

6. Severe Allergic Reactions:

   • Anaphylaxis, swelling of the face or throat, difficulty breathing.

Contraindications:

Hydrocortisone (Corbal 100) 100mg Powder for Injection is contraindicated in the following conditions:

1. Hypersensitivity to hydrocortisone or any component of the formulation.

2. Systemic Fungal Infections:

   • Use in patients with systemic fungal infections is contraindicated as hydrocortisone may worsen the condition.

3. Active Peptic Ulcer Disease:

   • Corticosteroids like hydrocortisone can exacerbate peptic ulcers.

4. Psychiatric Disorders:

   • Patients with uncontrolled mental health disorders may experience exacerbation of symptoms (e.g., mood swings, psychosis).

5. Live Vaccination:

   • Corticosteroid therapy can suppress the immune response, making live vaccines less effective and increasing the risk of infections from live vaccines.

Precautions:

1. Long-term Use:

   • Long-term use of corticosteroids should be avoided when possible due to the risk of Cushing's syndrome, osteoporosis, and other side effects.

2. Infection Risk:

   • Hydrocortisone suppresses the immune system and can mask the symptoms of an infection. Use with caution in patients with active infections.

3. Blood Sugar Monitoring:

   • Hydrocortisone may increase blood sugar levels. Patients with diabetes or those at risk of diabetes should be monitored.

4. Electrolyte Imbalances:

   • Hydrocortisone can cause sodium retention and potassium loss. Electrolyte levels should be monitored during treatment.

5. Tapering Off:

   • Corticosteroid therapy should not be stopped abruptly, especially after long-term use, due to the risk of adrenal insufficiency. Doses should be tapered gradually under a doctor's supervision.

Overdose:

Symptoms of overdose may include:

• Severe fluid retention, hypertension, hyperglycemia, and severe electrolyte imbalances.

• If overdose occurs, immediate medical intervention is required. Treatment focuses on managing symptoms and may involve reducing corticosteroid use, fluid and electrolyte monitoring, and controlling blood pressure and blood sugar levels.

Conclusion:

Hydrocortisone (Corbal 100) 100mg Powder for Injection is an effective corticosteroid used for acute inflammatory and autoimmune conditions, as well as in some cancer treatments. While it is highly effective in controlling inflammation and modulating the immune system, its use should be closely monitored due to potential side effects, especially with long-term therapy. It should be used cautiously in patients with a history of infection, gastrointestinal disease, or diabetes. Always follow your healthcare provider's guidance regarding dosing and monitoring during treatment.