Polymyxin B Sulfate + Neomycin Sulfate + Dexamethasone (Isore) 6000 Units/ 5mg/ 1mg per ml Sterile Opthalmic Solution 5ml

Generic Name: Polymyxin B Sulfate + Neomycin Sulfate + Dexamethasone

Brand Name: Isore

Strength: 6000 Units/ 5mg/ 1mg per ml 

Form: Opthalmic Solution

Manufacturer: Medilife Pharma, Inc.

Imported and Distributed by:

Classification: Antibacterial / Corticosteroid

Indication/Uses:

Polymyxin B Sulfate + Neomycin Sulfate + Dexamethasone, marketed as Isore in a sterile ophthalmic solution, is a combination medication used for treating certain eye conditions. The formulation includes 6000 units of polymyxin B sulfate, 5 mg of neomycin sulfate, and 1 mg of dexamethasone per ml. Here are the main indications and uses:

Indications and Uses

1. Bacterial Conjunctivitis:

   • Infection: Used to treat bacterial conjunctivitis (pink eye) caused by susceptible strains of bacteria. The polymyxin B and neomycin components provide antibacterial action.

2. Blepharitis:

   • Infection and Inflammation: Helps manage blepharitis (inflammation of the eyelid margins) associated with bacterial infections.

3. Post-Surgical Inflammation:

   • Inflammation Control: Used to reduce inflammation following eye surgery or trauma. The dexamethasone component helps control inflammation and alleviate symptoms such as redness, swelling, and discomfort.

4. Other Bacterial Eye Infections:

   • Broad-Spectrum Coverage: Effective for other bacterial infections of the eye where both antibacterial and anti-inflammatory treatment is required.

Mechanism of Action

• Polymyxin B Sulfate: An antibiotic that disrupts bacterial cell membrane function, leading to cell death. It is effective against Gram-negative bacteria.
• Neomycin Sulfate: An aminoglycoside antibiotic that inhibits bacterial protein synthesis, which leads to bacterial cell death. It targets a broad range of Gram-negative and some Gram-positive bacteria.
• Dexamethasone: A corticosteroid that reduces inflammation and allergic reactions by suppressing the immune response and decreasing the production of inflammatory mediators.

Dosage and Administration

• Typical Dosage: The usual dosage is 1 to 2 drops in the affected eye(s) every 3 to 4 hours, depending on the severity of the condition and the specific recommendations from the prescribing physician.
• Administration: The ophthalmic solution should be instilled directly into the eye(s). Ensure proper hygiene to avoid contamination of the dropper and solution.

Monitoring

• Ocular Health: Regular monitoring for signs of increased intraocular pressure or worsening of the infection.
• Systemic Effects: For prolonged use, monitor for systemic side effects related to corticosteroid use.

Polymyxin B Sulfate + Neomycin Sulfate + Dexamethasone (Isore) is a combination ophthalmic solution designed to provide both antibacterial and anti-inflammatory effects for the treatment of various eye conditions. Proper usage and adherence to prescribed treatment durations are crucial for achieving effective results and minimizing potential side effects.