Carbamazepine (Diamazepine) 200mg Tablet 100's

Certainly! Below is the detailed information for Carbamazepine (Diamazepine) 200mg Tablet 100's:

Product Description:

Carbamazepine (Diamazepine) is an anticonvulsant medication used primarily to treat epilepsy and certain neurological disorders. It works by stabilizing electrical activity in the brain, which helps to prevent and control seizures. It is also used to manage bipolar disorder and trigeminal neuralgia (a nerve pain disorder). Diamazepine comes in the form of 200mg tablets, and each pack contains 100 tablets.

Indications:

Carbamazepine (Diamazepine) is used for the treatment of the following conditions:

1. Epilepsy:

   • Carbamazepine is used to control partial seizures (both simple and complex) and generalized tonic-clonic seizures in patients with epilepsy.

2. Bipolar Disorder:

   • Carbamazepine is prescribed as a mood stabilizer to manage the manic and depressive episodes of bipolar disorder.

3. Trigeminal Neuralgia:

   • Carbamazepine is effective in treating the intense, stabbing facial pain associated with trigeminal neuralgia, a condition caused by dysfunction of the trigeminal nerve.

4. Other Neuropathic Pain:

   • Carbamazepine can be used in the treatment of neuropathic pain, including diabetic neuropathy and postherpetic neuralgia.

5. Other Off-label Uses:

   • Occasionally, Carbamazepine may be prescribed for restless leg syndrome and other conditions based on the doctor’s discretion.

Dosage:

The dosage of Carbamazepine (Diamazepine) varies depending on the condition being treated, the patient's response to therapy, and their age. Below are typical dosing guidelines for adults:

• For Epilepsy:

  • Initial Dose: The usual starting dose for adults is 200mg once or twice daily.

  • Titration: The dose may be gradually increased by 200mg every 3-4 days depending on the patient’s response and tolerability. The typical maintenance dose ranges from 800mg to 1,200mg per day.

  • Maximum Dose: The maximum recommended dose is 1,600mg per day in divided doses.

• For Bipolar Disorder:

  • The initial dose is usually 200mg once daily or twice daily, and the dose is gradually increased. The typical maintenance dose is between 400mg and 1,200mg per day, divided into two doses.

• For Trigeminal Neuralgia:

  • Carbamazepine is typically started at 100mg twice a day, with the dose gradually increased to 400mg to 800mg per day, divided into 2-4 doses.

• For Neuropathic Pain:

  • The usual starting dose is 100mg twice daily, gradually increasing to a maximum of 1,200mg per day.

Administration:

• The tablets should be taken with food to minimize gastrointestinal irritation.

• They should be swallowed whole with water; do not chew or crush the tablets.

Side Effects:

Carbamazepine (Diamazepine) can cause various side effects, ranging from mild to severe. Common side effects include:

Common Side Effects:

• Drowsiness or sedation.

• Dizziness or lightheadedness.

• Nausea or vomiting.

• Headache.

• Blurred vision or double vision.

• Ataxia (lack of coordination).

• Fatigue or tiredness.

• Loss of appetite.

• Dry mouth.

Serious Side Effects:

• Severe allergic reactions: Rash, swelling (especially in the face), or difficulty breathing.

• Blood disorders: This can include low white blood cell count (agranulocytosis), low platelets, and anemia. Regular blood tests are necessary to monitor these risks.

• Liver problems: Symptoms may include jaundice (yellowing of the skin or eyes), abdominal pain, and unusual fatigue.

• Severe mood changes: Some patients may experience depression, suicidal thoughts, or significant changes in behavior.

• Hyponatremia (low sodium levels), leading to confusion, lethargy, or seizures.

• Stevens-Johnson Syndrome: A rare but potentially life-threatening skin reaction with blisters, peeling skin, and fever.

• Heart arrhythmias: Carbamazepine may cause changes in heart rate, which can be particularly concerning for patients with heart disease.

If any serious side effects occur, immediate medical attention should be sought.

Contraindications:

Carbamazepine (Diamazepine) is contraindicated in the following conditions:

1. Hypersensitivity:

   • Contraindicated in patients with a known allergy to Carbamazepine or any of the excipients in the formulation.

2. Bone Marrow Depression:

   • Carbamazepine is contraindicated in patients with a history of bone marrow suppression, such as aplastic anemia, leukopenia, or thrombocytopenia.

3. Severe Liver Disease:

   • Carbamazepine is contraindicated in patients with active liver disease or hepatic impairment, as it can exacerbate liver damage.

4. Tricyclic Antidepressants (TCA) or Monoamine Oxidase Inhibitors (MAOIs):

   • Carbamazepine should not be used concomitantly with MAO inhibitors or tricyclic antidepressants due to the potential for serious interactions.

5. History of Skin Reactions to Anticonvulsants:

   • Carbamazepine should not be used in individuals with a history of severe skin reactions to anticonvulsants, such as Stevens-Johnson syndrome.

6. Pregnancy:

   • Carbamazepine is classified as Category D during pregnancy, meaning it may harm the fetus. It should only be used if absolutely necessary and under strict medical supervision. The medication may cause neural tube defects and other birth defects, so alternative treatments should be considered.

7. Breastfeeding:

   • Carbamazepine is excreted in breast milk, and its use during breastfeeding should be avoided unless the benefits outweigh the risks. Consult with a healthcare provider if you are breastfeeding or planning to breastfeed.

Precautions:

• Liver Function: Liver enzymes should be monitored during treatment. If any signs of liver dysfunction occur, such as jaundice, carbamazepine should be discontinued.

• Blood Monitoring: Regular blood tests should be conducted to monitor for blood dyscrasias (e.g., low white blood cells or low platelets).

• Seizure Control: Abrupt discontinuation of Carbamazepine may lead to withdrawal seizures. The dosage should be tapered gradually under medical supervision if discontinuation is required.

• Geriatric Use: Elderly patients may be more sensitive to the sedative effects of Carbamazepine and may require lower doses.

• Suicidal Thoughts: As with other anticonvulsants, there may be an increased risk of suicidal thoughts or behavior. Patients should be monitored for any changes in mood or behavior, especially at the start of treatment.

• Alcohol: Avoid consuming alcohol while taking Carbamazepine, as it can increase the sedative effects and increase the risk of side effects.

Drug Interactions:

Carbamazepine (Diamazepine) can interact with several medications, including:

• CYP450 Inhibitors and Inducers: Carbamazepine can either increase or decrease the effectiveness of other drugs that are metabolized by the CYP450 enzyme system. For example, CYP450 inducers (e.g., rifampin) can decrease Carbamazepine levels, while CYP450 inhibitors (e.g., erythromycin) can increase Carbamazepine levels, leading to toxicity.

• Other Antiepileptic Drugs: There may be interactions with other antiepileptic drugs, such as phenytoin, valproate, or phenobarbital, potentially altering seizure control or causing toxicity.

• Antidepressants: Carbamazepine may interact with tricyclic antidepressants (TCAs), leading to side effects such as drowsiness or cardiac arrhythmias.

• Oral Contraceptives: Carbamazepine can reduce the effectiveness of oral contraceptives, leading to unintended pregnancies.

Always inform your healthcare provider about all the medications you are taking, including prescription, over-the-counter drugs, and supplements.

Summary:

Carbamazepine (Diamazepine) is an anticonvulsant and mood stabilizer used to treat epilepsy, bipolar disorder, trigeminal neuralgia, and neuropathic pain. The typical dose for Carbamazepine 200mg tablets ranges from 200mg to 1,600mg daily, depending on the condition being treated.

Side effects may include drowsiness, dizziness, and nausea, with more serious effects including liver damage, blood disorders, and severe skin reactions. Carbamazepine is contraindicated in individuals with active liver disease, bone marrow suppression, or a history of severe skin reactions.

Patients should be monitored for liver function, blood counts, and mood changes, and Carbamazepine should not be used during pregnancy unless absolutely necessary.