Cefixime (Suprafix DS) 20mg/ml Powder for Oral Suspension (Oral Drops) 10ml

Antibacterial

Product Description:

Cefixime (Suprafix DS) 20mg/ml Powder for Oral Suspension (Oral Drops) is a broad-spectrum cephalosporin antibiotic used for the treatment of various bacterial infections. It is effective in treating infections by inhibiting the growth of bacteria. The suspension is specially formulated for easy administration in children and individuals who have difficulty swallowing tablets or capsules.

Each bottle contains 10ml of the suspension, providing a concentration of 20mg of cefixime per milliliter. After reconstitution, it can be administered as oral drops for effective treatment of bacterial infections.

Indications:

Cefixime (Suprafix DS) 20mg/ml Powder for Oral Suspension is indicated for the treatment of infections caused by susceptible organisms, including:

1. Upper Respiratory Tract Infections:

   • Acute otitis media (middle ear infections)

   • Pharyngitis (inflammation of the throat)

   • Tonsillitis

   • Sinusitis

2. Lower Respiratory Tract Infections:

   • Community-acquired pneumonia

   • Acute bronchitis

   • Exacerbation of chronic obstructive pulmonary disease (COPD)

3. Urinary Tract Infections:

   • Cystitis (bladder infections)

   • Pyelonephritis (kidney infections)

4. Gastrointestinal Infections:

   • Salmonella infections

   • Shigellosis

5. Other Infections:

   • Gonorrhea (a sexually transmitted bacterial infection)

   • Infections caused by other susceptible bacteria

Dosage and Administration:

The recommended dosage of Cefixime (Suprafix DS) Oral Suspension depends on the age of the patient and the severity of the infection:

1. Adults:

   • Typical dose: 400mg once daily or 200mg twice daily for most infections, but the dose may vary depending on the infection and severity.

2. Children (based on weight and age):

   • For children aged 6 months to 12 years, the typical dosage is 8mg/kg/day in divided doses (once or twice a day).

   • Infants aged 6 months to 12 years: A typical dose is 4-8mg/kg/day depending on the infection.

   After reconstitution, the suspension is usually administered once or twice daily, depending on the doctor’s recommendation.

   Note: It's essential to follow the instructions on the label and adjust the dose based on the healthcare provider’s advice, especially in children and infants.

Side Effects:

Common side effects of Cefixime (Suprafix DS) Oral Suspension include:

1. Gastrointestinal Symptoms:

   • Diarrhea (often mild)

   • Nausea

   • Vomiting

   • Abdominal pain

   • Indigestion

2. Skin Reactions:

   • Rash or itching

   • Urticaria (hives)

3. CNS Effects:

   • Headache or dizziness (less common)

4. General Effects:

   • Fatigue or tiredness

   • Fever

Serious Side Effects (Rare but require immediate medical attention):

1. Severe Allergic Reactions:

   • Swelling of the face, lips, tongue, or throat (angioedema)

   • Difficulty breathing

   • Anaphylactic reactions

2. Gastrointestinal Issues:

   • Severe diarrhea (possibly Clostridium difficile-associated diarrhea)

   • Blood in stools or severe abdominal pain

3. Hepatic Issues:

   • Jaundice (yellowing of skin or eyes)

   • Dark urine

   • Unexplained fatigue or weakness

4. Hematologic Reactions:

   • Unusual bruising or bleeding (may indicate blood disorders)

   • Anemia (low red blood cell count)

5. Kidney Problems:

   • Decreased urine output

   • Swelling or puffiness in the legs, ankles, or feet

Contraindications:

Cefixime (Suprafix DS) Oral Suspension should not be used in the following situations:

1. Allergy to Cefixime or Cephalosporins: Patients with a known allergy to cephalosporin antibiotics (such as cefixime) or any of the components in the suspension should not use this medication.

2. Severe Renal Impairment: Use with caution in patients with severe kidney problems, as the medication is eliminated through the kidneys and could lead to a higher concentration in the bloodstream.

3. Severe Gastrointestinal Conditions: Individuals with a history of severe gastrointestinal issues like colitis (inflammation of the colon) may be at risk of further complications.

4. Penicillin Allergy: Cross-reactivity may occur between penicillin and cephalosporins, so patients with a known penicillin allergy should be carefully monitored when taking cefixime.

Warnings and Precautions:

• Superinfection: Prolonged use of antibiotics may result in a secondary infection (such as a yeast infection or Clostridium difficile infection), requiring discontinuation or additional treatment.

• Renal Function: Dose adjustments may be needed for individuals with renal impairment, as cefixime is primarily eliminated by the kidneys.

• Pregnancy and Breastfeeding: Cefixime is classified as a Category B drug for pregnancy, meaning it has not been shown to cause harm to the fetus. It can be used during pregnancy if prescribed by a doctor. Cefixime is excreted into breast milk in small amounts, so it should only be used during breastfeeding if necessary and under medical supervision.

• Drug Interactions: Cefixime may interact with other drugs, including anticoagulants like warfarin and other antibiotics, so it's important to inform the healthcare provider of all medications being taken.

Storage:

• Store at room temperature (15°C to 30°C / 59°F to 86°F).

• Reconstituted suspension should be stored in the refrigerator and used within 14 days.

• Keep out of reach of children.

Conclusion:

Cefixime (Suprafix DS) 20mg/ml Powder for Oral Suspension is an effective antibiotic used to treat a wide range of bacterial infections, including respiratory, urinary tract, and gastrointestinal infections. It is particularly useful for children and those who have difficulty swallowing pills. As with any antibiotic, it is important to complete the full course of treatment to prevent the development of antibiotic-resistant bacteria. Always follow the prescribed dosage and consult with a healthcare provider for any concerns or side effects.