Cefuroxime Sodium (Cefopti) 750mg Powder for Injection (I.M/I.V) Antibacterial Vials 10's

Here's the detailed information for Cefuroxime Sodium (Cefopti) 750mg Powder for Injection (I.M/I.V) Antibacterial Vials 10's:

Product Description:

Cefuroxime Sodium (Cefopti) 750mg is an antibacterial agent that belongs to the cephalosporin class of antibiotics. It is used to treat a variety of bacterial infections by inhibiting bacterial cell wall synthesis, leading to the death of the bacteria. This formulation comes as a 750mg powder that is reconstituted with a suitable diluent before administration by intravenous (IV) or intramuscular (IM) injection.

Each vial contains 750mg of Cefuroxime sodium, and the pack contains 10 vials. Cefuroxime is effective against a broad spectrum of both Gram-positive and Gram-negative bacteria.

Indications:

Cefuroxime (Cefopti) 750mg is indicated for the treatment of infections caused by susceptible bacteria. It is used in various types of bacterial infections, including but not limited to:

1. Respiratory Tract Infections:

   • Pneumonia

   • Acute exacerbations of chronic bronchitis

   • Acute sinusitis

2. Urinary Tract Infections:

   • Pyelonephritis

   • Cystitis

3. Skin and Soft Tissue Infections:

   • Cellulitis

   • Wound infections

4. Bone and Joint Infections:

   • Osteomyelitis

   • Septic arthritis

5. Meningitis (when caused by susceptible bacteria)

6. Gonorrhea:

   • Cefuroxime is effective in treating uncomplicated gonorrhea caused by Neisseria gonorrhoeae.

7. Prophylaxis for Surgical Infections:

   • As a preventive measure in surgeries, particularly those involving the abdominal, orthopedic, or gynecological areas.

Dosages:

The dosing of Cefuroxime (Cefopti) 750mg depends on the type and severity of the infection, as well as the patient’s age, kidney function, and overall condition.

For Adults:

• Pneumonia: 750mg to 1.5g every 8 hours (IV/IM).

• Skin and Soft Tissue Infections: 750mg to 1.5g every 8 hours (IV/IM).

• Urinary Tract Infections: 750mg to 1.5g every 8 hours (IV/IM).

• Meningitis: 3g every 8 hours (IV).

• Gonorrhea: A single 750mg dose (IM/IV).

For Pediatric Patients:

• Infants (up to 3 months): 50mg/kg every 8 hours (IV/IM).

• Children (3 months and older): 50mg/kg every 8 hours (IV/IM).

  • The maximum dose should not exceed 1.5g per dose.

Prophylaxis (Pre-surgical):

• 1.5g administered 30 minutes to 1 hour before surgery.

Adjustments for Renal Impairment:

• Severe renal impairment: The dose may need to be reduced or spaced out depending on the degree of impairment. Consult a healthcare provider for appropriate adjustments.

Side Effects:

Cefuroxime (Cefopti) is generally well-tolerated, but like any medication, it can cause side effects. Common and serious side effects include:

Common Side Effects:

1. Gastrointestinal issues:

   • Nausea

   • Vomiting

   • Diarrhea

   • Abdominal pain

2. Injection site reactions:

   • Pain or swelling at the injection site (especially with IM injection).

3. Rash:

   • Mild rashes may occur.

4. Fever:

   • Temporary fever during treatment.

Serious Side Effects:

1. Allergic reactions:

   • Anaphylaxis (a severe allergic reaction).

   • Angioedema (swelling of the skin and mucous membranes).

   • Rash or hives.

2. Hematological reactions:

   • Thrombocytopenia (low platelet count).

   • Leukopenia (low white blood cell count).

   • Eosinophilia (high eosinophil count).

3. Kidney issues:

   • Renal impairment or acute kidney failure, particularly in patients with preexisting kidney disease.

4. Liver toxicity:

   • Elevated liver enzymes or hepatitis.

5. Severe diarrhea:

   • Could indicate Clostridium difficile infection, which can cause serious colitis.

6. Superinfection:

   • Prolonged use of antibiotics can lead to overgrowth of non-susceptible organisms like Candida or Clostridium difficile.

Contraindications:

Cefuroxime (Cefopti) should not be used in the following situations:

1. Hypersensitivity to Cefuroxime or Cephalosporins:

   • Contraindicated in patients who have a known allergy to Cefuroxime or other cephalosporin antibiotics.

2. Severe Allergic Reactions to Penicillins:

   • Caution is needed in patients with a history of severe allergic reactions (e.g., anaphylaxis) to penicillin antibiotics. Cross-reactivity may occur between penicillins and cephalosporins in a small percentage of patients.

3. Renal Impairment:

   • Cefuroxime should be used cautiously or avoided in patients with severe renal impairment, unless dose adjustments are made.

4. Pregnancy (Category B):

   • Cefuroxime is generally considered safe to use during pregnancy, but it should be used only if the potential benefits outweigh the risks. Always consult a healthcare provider before use.

5. Breastfeeding:

   • Cefuroxime is excreted into breast milk in small amounts. It is usually considered safe to use during breastfeeding, but caution is recommended. Consult with a healthcare provider for specific advice.

Precautions:

1. Renal Function:

   • Cefuroxime should be used with caution in patients with renal impairment, and dosage adjustments may be required. Monitoring of kidney function during treatment is advised.

2. Gastrointestinal Disorders:

   • Caution should be used in patients with a history of gastrointestinal conditions such as colitis or ulcerative colitis, as antibiotics can trigger flare-ups.

3. Pregnancy and Lactation:

   • Though Cefuroxime is typically considered safe during pregnancy, it should be used only when clearly needed. It's important to consult a doctor if pregnant or breastfeeding.

4. Anticoagulants:

   • Cefuroxime may enhance the effects of oral anticoagulants (e.g., warfarin), increasing the risk of bleeding. Careful monitoring of coagulation parameters is recommended.

5. Monitoring:

   • Regular blood counts and renal function monitoring should be considered in prolonged therapy, particularly in patients with underlying renal or hepatic disease.

Summary:

Cefuroxime Sodium (Cefopti) 750mg is an injectable antibacterial used to treat a wide range of bacterial infections, including respiratory, urinary, and skin infections, among others. It is also used for surgical prophylaxis and the treatment of gonorrhea. The typical dose for adults is 750mg to 1.5g every 8 hours, while for children, the dose is based on weight.

Common side effects include gastrointestinal discomfort, rash, and injection site reactions. Serious side effects include allergic reactions, renal impairment, and liver toxicity. Cefuroxime should not be used in patients with a history of severe allergies to cephalosporins or penicillins. It should also be used with caution in patients with renal impairment.