Ciprofloxacin (Ciprodin FC) 500mg Tablet 100's

Here's the detailed information for Ciprofloxacin (Ciprodin FC) 500mg Tablet 100's:

Product Description:

Ciprofloxacin (Ciprodin FC) 500mg is a fluoroquinolone antibiotic used to treat a wide range of bacterial infections. It works by inhibiting the bacterial DNA-gyrase enzyme, which is essential for DNA replication, leading to the death of the bacteria.

Each Ciprodin FC 500mg tablet contains 500mg of Ciprofloxacin as the active ingredient and is available in packs of 100 tablets. The tablet is film-coated to ensure easy swallowing and to protect the active ingredients from degradation due to moisture and light.

Indications:

Ciprofloxacin (Ciprodin FC) 500mg is used to treat various bacterial infections, including:

1. Urinary Tract Infections (UTIs):

   • Treatment of uncomplicated and complicated UTIs caused by susceptible organisms.

2. Respiratory Tract Infections:

   • Pneumonia, bronchitis, and sinusitis caused by susceptible bacteria.

3. Skin and Soft Tissue Infections:

   • Including cellulitis, abscesses, and other superficial and deep skin infections.

4. Bone and Joint Infections:

   • Including osteomyelitis (bone infection) and septic arthritis.

5. Gastrointestinal Infections:

   • For infections like enteritis caused by certain bacteria such as Salmonella, Shigella, and Campylobacter.

6. Intra-abdominal Infections:

   • Used in combination with other antibiotics for conditions like peritonitis and intra-abdominal abscesses.

7. Typhoid Fever:

   • Treatment of typhoid fever caused by Salmonella species.

8. Anthrax Exposure (Post-exposure prophylaxis):

   • Ciprofloxacin is used as a preventive measure in case of potential anthrax exposure.

Dosages:

The dosage of Ciprofloxacin (Ciprodin FC) 500mg tablets depends on the infection being treated. Below are the general dosage guidelines for adults:

For Adults:

1. Urinary Tract Infections:

   • 250mg to 500mg every 12 hours for 7 to 14 days depending on the severity and type of infection.

2. Respiratory Tract Infections:

   • 500mg every 12 hours for 7 to 14 days (for uncomplicated cases).

   • 750mg every 12 hours for severe or complicated infections.

3. Skin and Soft Tissue Infections:

   • 500mg every 12 hours for 7 to 14 days depending on severity.

4. Bone and Joint Infections:

   • 500mg to 750mg every 12 hours, usually for 4 to 6 weeks.

5. Gastrointestinal Infections:

   • 500mg every 12 hours for 5 to 7 days.

6. Intra-abdominal Infections:

   • 500mg every 12 hours, often in combination with other antibiotics.

7. Typhoid Fever:

   • 500mg every 12 hours for 10 to 14 days.

8. Anthrax Prophylaxis:

   • 500mg every 12 hours for 60 days following potential exposure.

Renal Impairment:

• Dosage adjustments may be needed in patients with renal dysfunction. In cases of severe renal impairment, the dose may be reduced, or the dosing interval extended.

Pediatric Patients:

• Ciprofloxacin can be used in children (aged 1 year or older) for certain infections such as cystic fibrosis-related infections or severe infections, but the dosage should be based on the weight of the child and prescribed by a healthcare provider.

Side Effects:

Common and serious side effects of Ciprofloxacin (Ciprodin FC) include:

Common Side Effects:

1. Gastrointestinal Issues:

   • Nausea, vomiting, diarrhea, stomach cramps, or bloating.

2. Headache: May occur, usually mild.

3. Dizziness or light-headedness.

4. Rash: Skin rashes or itching.

5. Sleep Disturbances: Insomnia or vivid dreams in some cases.

Serious Side Effects:

1. Tendon Damage:

   • Tendinitis or tendon rupture, especially in the Achilles tendon. Older adults or those on corticosteroid therapy are at higher risk.

2. QT Prolongation:

   • Can cause arrhythmias or irregular heart rhythms, especially in patients with pre-existing heart conditions.

3. Severe Allergic Reactions:

   • Symptoms include difficulty breathing, swelling of the face, lips, tongue, or throat (anaphylaxis).

4. Severe Skin Reactions:

   • Conditions like Stevens-Johnson syndrome or toxic epidermal necrolysis.

5. Liver Toxicity:

   • Elevated liver enzymes or jaundice (yellowing of the skin or eyes).

6. Clostridium difficile Infection:

   • Prolonged use can lead to C. difficile-associated diarrhea, which can be severe.

7. Seizures:

   • Ciprofloxacin can lower the seizure threshold, particularly in those with a history of seizures.

8. Mental Health Effects:

   • Anxiety, hallucinations, depression, and confusion may occur in some patients.

Other Effects:

• Photosensitivity (increased sensitivity to sunlight).

• Hypoglycemia or hyperglycemia (especially in diabetic patients).

Contraindications:

Ciprofloxacin (Ciprodin FC) should not be used in the following cases:

1. Hypersensitivity:

   • Known allergy to Ciprofloxacin or other fluoroquinolones.

2. Tendon Disorders:

   • Patients with a history of tendinitis or tendon rupture related to fluoroquinolone use.

3. Pregnancy:

   • Category C: Ciprofloxacin should be used during pregnancy only if the benefits outweigh the potential risks. It is generally avoided during pregnancy, especially during the first trimester.

4. Breastfeeding:

   • Ciprofloxacin is excreted in breast milk and should be avoided in breastfeeding mothers, unless the benefits outweigh the risks.

5. Children Under 18 Years:

   • Ciprofloxacin is not recommended for children under 18 unless for specific serious infections (e.g., cystic fibrosis). It may affect cartilage development in growing children.

6. Severe Renal Impairment:

   • Use with caution in patients with severe renal impairment.

7. Myasthenia Gravis:

   • Ciprofloxacin may worsen muscle weakness in patients with myasthenia gravis.

8. QT Prolongation:

   • Ciprofloxacin should be avoided in patients with a known history of QT interval prolongation or those on antiarrhythmic drugs that prolong the QT interval.

Precautions:

1. Hydration:

   • Ensure adequate fluid intake to prevent crystalluria (crystals in the urine).

2. Drug Interactions:

   • Ciprofloxacin can interact with other medications, including:

     • Antacids, iron supplements, or multivitamins (which may reduce Ciprofloxacin absorption).

     • Warfarin (Ciprofloxacin can enhance the effects of warfarin, increasing the risk of bleeding).

     • Corticosteroids (increased risk of tendon damage).

3. Seizures:

   • Use Ciprofloxacin cautiously in patients with a history of seizures or those with central nervous system disorders.

4. Sun Exposure:

   • Ciprofloxacin can make the skin more sensitive to sunlight, leading to sunburns. Avoid excessive sun exposure and use sunscreen.

5. Diabetes:

   • Ciprofloxacin may affect blood glucose levels, and diabetic patients should monitor their blood sugar levels closely.

Summary:

Ciprofloxacin (Ciprodin FC) 500mg tablet is an antibacterial medication used to treat a wide range of bacterial infections, including UTIs, respiratory infections, skin infections, and gastrointestinal infections. It is generally dosed at 500mg every 12 hours for adults, but the duration and dosage may vary based on the infection type.

Common side effects include nausea, headache, and diarrhea, while more serious effects like tendon rupture, QT prolongation, and severe allergic reactions can occur but are rare. Ciprofloxacin is contraindicated in pregnant women, breastfeeding mothers, and children under 18, except for specific conditions.

Patients should follow the prescribed dosage and monitor for any severe reactions during treatment.