Bambang Pharmaceutical Depot Inc.
Ciprofloxacin (Ciprofed) 500mg Tablet 100's
Ciprofloxacin (Ciprofed) 500mg Tablet 100's
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Here is the detailed information for Ciprofloxacin (Ciprofed) 500mg Tablet 100's:
Product Description:
Ciprofloxacin (Ciprofed) 500mg is an antibiotic belonging to the class of fluoroquinolones. It works by inhibiting bacterial DNA synthesis, preventing bacteria from replicating and growing. This makes Ciprofloxacin effective against a wide range of bacterial infections.
Each Ciprofed tablet contains 500mg of Ciprofloxacin as the active ingredient, and it is available in packs of 100 tablets.
Ciprofloxacin is commonly prescribed to treat infections caused by susceptible bacteria, and it is available in tablet form for oral administration.
Indications:
Ciprofloxacin (Ciprofed) is used to treat a variety of bacterial infections, including:
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Urinary Tract Infections (UTIs):
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Including cystitis and pyelonephritis, caused by susceptible bacteria.
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Respiratory Tract Infections:
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Such as pneumonia, bronchitis, and sinusitis, caused by susceptible organisms.
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Skin and Soft Tissue Infections:
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Includes infections like cellulitis, wound infections, and abscesses.
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Bone and Joint Infections:
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Including infections like osteomyelitis and septic arthritis.
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Gastrointestinal Infections:
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Such as enteritis caused by certain bacteria (e.g., Shigella or Salmonella).
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Intra-abdominal Infections:
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Used in combination with other antibiotics for conditions like peritonitis or intra-abdominal abscesses.
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Typhoid Fever:
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Caused by Salmonella species, particularly in areas where drug resistance is common.
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Bacterial Diarrhea:
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Treatment for gastroenteritis caused by certain bacteria.
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Anthrax Exposure (Post-exposure prophylaxis):
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Ciprofloxacin is also used for prophylaxis and treatment in cases of anthrax exposure.
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Dosages:
The dosage of Ciprofloxacin (Ciprofed) depends on the severity of the infection, the specific bacteria involved, and the patient's overall health condition. Below are the general dosing guidelines:
For Adults:
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Urinary Tract Infections:
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250mg to 500mg every 12 hours for 7 to 14 days.
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Respiratory Tract Infections:
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500mg every 12 hours for 7 to 14 days (for uncomplicated cases). Severe infections may require higher doses or longer treatment.
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Skin and Soft Tissue Infections:
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500mg every 12 hours for 7 to 14 days.
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Bone and Joint Infections:
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500mg to 750mg every 12 hours, usually for 4 to 6 weeks.
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Gastrointestinal Infections:
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500mg every 12 hours for 5 to 7 days.
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Intra-abdominal Infections:
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500mg every 12 hours, often in combination with other antibiotics.
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Typhoid Fever:
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500mg every 12 hours for 10 to 14 days.
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Anthrax Prophylaxis:
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500mg every 12 hours for 60 days after exposure.
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Renal Impairment:
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Dosage adjustments may be necessary in patients with renal impairment. In cases of severe renal dysfunction, the dosing interval may be extended.
Pediatric Patients:
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The dosage in children depends on the type of infection and the child's weight. Ciprofloxacin is generally used for children over 1 year of age with certain infections, but the dose should be prescribed by a healthcare provider based on the specific condition.
Side Effects:
Ciprofloxacin (Ciprofed) is generally well tolerated, but it can cause side effects. Common and serious side effects include:
Common Side Effects:
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Gastrointestinal Issues:
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Nausea, vomiting, diarrhea, abdominal pain.
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Headache: A common but mild side effect.
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Dizziness: May occur in some individuals, particularly when standing up.
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Rash: Skin rashes or itching may occur.
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Sleep Disturbances: Insomnia or nightmares may be experienced.
Serious Side Effects:
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Tendon Damage: Tendinitis or tendon rupture, especially in the Achilles tendon (more common in elderly patients or those on corticosteroid therapy).
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QT Prolongation: Ciprofloxacin may cause a prolonged QT interval on an electrocardiogram, leading to arrhythmias.
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Severe Allergic Reactions (Anaphylaxis):
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Symptoms include difficulty breathing, swelling of the face, lips, tongue, or throat.
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Severe Skin Reactions:
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Stevens-Johnson syndrome, toxic epidermal necrolysis (rare but serious).
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Liver Toxicity:
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Elevated liver enzymes or jaundice (yellowing of the skin/eyes).
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Severe Diarrhea: Can occur as a result of Clostridium difficile infection.
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Seizures: Ciprofloxacin can lower the seizure threshold, especially in individuals with a history of seizures.
Mental Health Issues:
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In rare cases, psychiatric reactions such as anxiety, depression, hallucinations, or confusion may occur.
Contraindications:
Ciprofloxacin (Ciprofed) should not be used in the following situations:
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Hypersensitivity:
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Known allergy to ciprofloxacin or other fluoroquinolones.
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Tendon Disorders:
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History of tendinitis or tendon rupture associated with fluoroquinolone use.
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Pregnancy:
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Category C: Ciprofloxacin should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is generally not recommended during pregnancy unless absolutely necessary.
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Breastfeeding:
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Ciprofloxacin is excreted in breast milk and should be avoided or used with caution in nursing mothers.
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Children Under 18 Years:
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Ciprofloxacin is not recommended for use in children under 18 except for certain serious infections (e.g., cystic fibrosis-related infections). It can affect cartilage development in growing children.
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Severe Renal or Hepatic Dysfunction:
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Use with caution in patients with severe renal impairment or liver disease.
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Myasthenia Gravis:
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Ciprofloxacin may exacerbate muscle weakness in patients with myasthenia gravis and should be avoided in these patients.
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Precautions:
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Drug Interactions:
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Ciprofloxacin can interact with other medications, including:
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Antacids or iron supplements (can reduce absorption).
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Warfarin (may increase the risk of bleeding).
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Corticosteroids (increased risk of tendon damage).
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QT-prolonging drugs (can increase the risk of arrhythmias).
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Hydration:
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Drink plenty of fluids while taking Ciprofloxacin to avoid the formation of crystals in the urine.
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Seizure Risk:
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Use with caution in patients with a history of seizures or those on medications that lower the seizure threshold.
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Sun Sensitivity:
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Ciprofloxacin can increase sensitivity to sunlight. Avoid prolonged exposure to sunlight or tanning beds and use sunscreen during treatment.
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C. difficile Infection:
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Prolonged or inappropriate use of Ciprofloxacin can lead to Clostridium difficile-associated diarrhea (CDAD), which can be severe and may require discontinuation of the drug.
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Summary:
Ciprofloxacin (Ciprofed) 500mg tablet is a fluoroquinolone antibiotic used to treat various bacterial infections, including UTIs, respiratory infections, skin infections, and gastrointestinal infections. The standard adult dose is 500mg every 12 hours, but the duration and dosage can vary depending on the type and severity of the infection.
Common side effects include nausea, headache, and diarrhea, while serious effects like tendon damage, seizures, and severe allergic reactions are possible but rare. Ciprofloxacin is contraindicated in individuals with a known allergy to the drug, in pregnant or breastfeeding women, and in children under 18, except in special cases.
Patients should be closely monitored for potential side effects, especially if they have renal, hepatic, or neurological conditions. Always follow the prescribed dosage and seek medical attention if any severe reactions occur.
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