Bambang Pharmaceutical Depot Inc.
Clindamycin Hydrochloride (Clindagold) 150mg Capsule 100's
Clindamycin Hydrochloride (Clindagold) 150mg Capsule 100's
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Here is the detailed information for Clindamycin Hydrochloride (Clindagold) 150mg Capsule 100's:
Product Description:
Clindamycin Hydrochloride (Clindagold) 150mg Capsules are an antibiotic medication primarily used to treat a variety of bacterial infections. The active ingredient, Clindamycin, is a lincosamide antibiotic that works by inhibiting bacterial protein synthesis, which prevents the bacteria from growing and multiplying. It is effective against a broad spectrum of gram-positive bacteria and anaerobic bacteria.
Each capsule contains 150mg of Clindamycin Hydrochloride, and the product is available in a bottle of 100 capsules. This formulation is typically used for oral administration to treat infections in different parts of the body, including the skin, respiratory system, and bone.
Indications:
Clindamycin Hydrochloride (Clindagold) is indicated for the treatment of the following infections:
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Respiratory Tract Infections:
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Includes pneumonia, bronchitis, and sinusitis, often caused by Streptococcus pneumoniae, Staphylococcus aureus, and Haemophilus influenzae.
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Skin and Soft Tissue Infections:
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Includes conditions like cellulitis, abscesses, furuncles, and boils caused by Staphylococcus aureus or Streptococcus pyogenes.
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Bone and Joint Infections:
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Osteomyelitis and infections of bones and joints caused by susceptible bacteria.
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Intra-abdominal Infections:
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Infections like peritonitis and intra-abdominal abscesses, particularly caused by anaerobic bacteria.
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Pelvic Infections:
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Pelvic inflammatory disease (PID) and endometritis caused by susceptible organisms.
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Dental Infections:
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Dental abscesses, gum infections, and other oral infections caused by anaerobic bacteria.
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Septicemia and Bloodstream Infections:
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Bacteremia (bacterial infection in the blood) caused by susceptible organisms.
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Toxic Shock Syndrome:
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Caused by Staphylococcus aureus or Streptococcus pyogenes.
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Dosages:
The dosage of Clindamycin Hydrochloride (Clindagold) 150mg Capsules will depend on the severity of the infection, the patient’s age, weight, and overall health status.
For Adults:
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Respiratory, Skin, and Soft Tissue Infections:
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150mg to 450mg every 6 to 8 hours, depending on the severity of the infection.
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Bone and Joint Infections:
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150mg to 450mg every 6 to 8 hours.
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Intra-abdominal Infections:
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150mg to 450mg every 6 hours, often in combination with other antibiotics for full-spectrum coverage.
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Pelvic Infections:
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150mg to 300mg every 6 hours, depending on severity.
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Severe Infections (e.g., septicemia, toxic shock syndrome):
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300mg to 450mg every 6 hours.
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For Children:
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Pediatric dosages are based on body weight:
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The typical dose for children is 8 to 40 mg/kg/day, divided into 3 or 4 doses. The exact dose will depend on the infection and its severity.
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For Renal or Hepatic Impairment:
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Clindamycin does not require significant dose adjustment for renal impairment, but hepatic impairment should be monitored carefully, and doses may need to be adjusted based on liver function.
Side Effects:
Clindamycin Hydrochloride (Clindagold) can cause side effects, although not everyone experiences them. Common side effects include:
Common Side Effects:
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Gastrointestinal issues: nausea, vomiting, diarrhea, and abdominal discomfort.
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Metallic taste.
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Rash: Mild skin rash may occur.
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Fatigue or general feeling of discomfort.
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Mild headache.
Serious Side Effects:
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Clostridium difficile-associated Diarrhea (CDAD):
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A potentially life-threatening condition where Clostridium difficile bacteria overgrow in the intestines, causing severe diarrhea, fever, and abdominal cramps.
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Liver Dysfunction (Hepatotoxicity):
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Rare but can cause elevated liver enzymes, hepatitis, or jaundice (yellowing of the skin or eyes).
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Severe Allergic Reactions (Anaphylaxis):
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Symptoms include difficulty breathing, swelling of the face, lips, or throat, and hives. Immediate medical attention is required.
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Blood Disorders:
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Rare cases of thrombocytopenia (low platelet count), leukopenia (low white blood cell count), and agranulocytosis (severe drop in white blood cells).
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Esophageal Irritation:
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If the capsules are taken without sufficient water or if the patient lies down immediately after ingestion, there is an increased risk of esophageal irritation or even ulceration.
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Myopathy (muscle damage):
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Rare but can cause muscle weakness or pain.
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Contraindications:
Clindamycin Hydrochloride (Clindagold) 150mg Capsules are contraindicated in the following situations:
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Hypersensitivity:
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Contraindicated in patients with known allergy to Clindamycin, Lincomycin, or any components of the product.
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History of Colitis:
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Clindamycin should not be used in patients with a history of colitis, especially Clostridium difficile-associated diarrhea (CDAD), as the drug can worsen these conditions.
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Severe Liver Disease:
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Use with caution or avoid in patients with severe hepatic impairment, as there is a potential risk for hepatotoxicity.
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Pregnancy:
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Pregnancy Category B: Clindamycin is generally considered safe during pregnancy but should only be used when the potential benefits outweigh the risks. Consult a healthcare provider before using Clindamycin during pregnancy.
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Breastfeeding:
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Clindamycin is excreted in breast milk, and although it is generally considered safe during breastfeeding, it should be used with caution. Consult with a healthcare provider before using Clindamycin while breastfeeding.
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Precautions:
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Gastrointestinal Conditions:
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Patients with a history of gastrointestinal disease, especially inflammatory bowel disease (e.g., Crohn's disease or ulcerative colitis), should use Clindamycin with caution.
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Renal and Hepatic Impairment:
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Clindamycin does not require dose adjustment for renal impairment, but caution is advised for patients with liver disease, as the drug is metabolized in the liver.
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Superinfection:
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Clindamycin can lead to superinfections due to overgrowth of non-susceptible organisms, including yeast and C. difficile. If a superinfection occurs, treatment should be reassessed.
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Proper Administration:
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The capsule should be taken with a full glass of water to reduce the risk of esophageal irritation. Patients should avoid lying down immediately after taking the medication.
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Prolonged Use:
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Long-term use may increase the risk of resistant infections. Patients should complete the full prescribed course, even if they feel better, to prevent the development of antibiotic resistance.
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Summary:
Clindamycin Hydrochloride (Clindagold) 150mg Capsules are an effective antibiotic for treating serious bacterial infections, including respiratory, skin, bone, and intra-abdominal infections. The typical dose for adults ranges from 150mg to 450mg every 6 to 8 hours depending on the severity and type of infection.
Possible side effects include gastrointestinal issues, rash, and in rare cases, more severe reactions like Clostridium difficile diarrhea, liver dysfunction, or severe allergic reactions. It is contraindicated in patients with a history of colitis or severe liver disease and should be used cautiously during pregnancy and breastfeeding.
As with any antibiotic, it’s important to follow the prescribed regimen and complete the full course to avoid antibiotic resistance and ensure optimal treatment outcomes. Always consult with a healthcare provider before starting treatment.
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