Glibenclamide 5mg Tablet 100's

Generic Name: GLIBENCLAMIDE

Brand Name: GLIMIDE

Strength: 5mg

Form: TABLET

Manufacturer:  JIANGXI XIERKANGTAI PHARMACEUTICAL CO., LTD. 

Imported and Distributed by: PHILRX PHARMA INC.

Classification: SULFONYLUREA

Indication/Uses: 

1. Blood Sugar Control:

   • Mechanism of Action: Glibenclamide helps lower blood glucose levels by stimulating the release of insulin from the pancreas. It works by binding to specific receptors on pancreatic beta cells, promoting insulin secretion.
   • Improved Glycemic Control: Effective in reducing fasting blood glucose and postprandial (after meal) blood glucose levels, helping to maintain overall glycemic control.

2. Reduction in Diabetes-Related Complications:

   • Cardiovascular Health: By maintaining blood sugar levels within a normal range, glibenclamide can help reduce the risk of cardiovascular complications associated with diabetes, such as heart disease and stroke.
   • Neuropathy Prevention: Proper glycemic control helps in preventing diabetic neuropathy, a condition characterized by nerve damage due to prolonged high blood sugar levels.
   • Nephropathy Prevention: Consistent control of blood glucose levels can also reduce the risk of diabetic nephropathy, which is kidney damage resulting from chronic high blood sugar levels.

3. Accessibility and Cost-Effectiveness:

   • Widely Available: Glibenclamide is a widely prescribed oral hypoglycemic agent, making it easily accessible for many patients.
   • Cost-Effective Treatment: As a generic medication, it is often more affordable compared to some of the newer diabetes medications, making it a cost-effective option for long-term diabetes management.

Indications and Uses

• Type 2 Diabetes Mellitus: Glibenclamide is specifically indicated for the treatment of type 2 diabetes when diet and exercise alone do not provide adequate glycemic control.
• Combination Therapy: It can be used as monotherapy or in combination with other antidiabetic agents, such as metformin, to achieve better blood glucose control.

Precautions and Considerations

• Hypoglycemia Risk: One of the main side effects of glibenclamide is hypoglycemia (low blood sugar). Patients must monitor their blood sugar levels regularly and be aware of the signs and symptoms of hypoglycemia.
• Not Suitable for Type 1 Diabetes: Glibenclamide is not effective for treating type 1 diabetes or diabetic ketoacidosis.
• Potential Drug Interactions: It can interact with other medications, so it is important for patients to inform their healthcare provider of all medications they are taking.

Conclusion

Glibenclamide 5mg tablets are an effective and widely used option for managing type 2 diabetes. By stimulating insulin release and improving glycemic control, it helps prevent the complications associated with chronic high blood sugar levels. However, it is important to use this medication under the guidance of a healthcare professional due to the risk of hypoglycemia and potential drug interactions.

For more detailed information, patients should consult with their healthcare provider or refer to reliable medical resources.