Gliclazide (Zebet) 80mg Tablet 100's

Gliclazide (Zebet) 80mg Tablet 100's

Product Description:

Zebet 80mg contains Gliclazide, an oral hypoglycemic agent in the class of sulfonylureas. It is primarily used in the treatment of type 2 diabetes mellitus. Gliclazide works by stimulating the pancreas to release insulin and increasing the sensitivity of tissues to insulin. This helps to lower blood sugar levels in diabetic patients. Zebet 80mg is available as a film-coated tablet, with each bottle containing 100 tablets.

Indications:

Zebet (Gliclazide) is indicated for the treatment of type 2 diabetes mellitus, particularly in the following situations:

1. Type 2 Diabetes Mellitus (Non-insulin-dependent diabetes):

   • Used as an adjunct to diet and exercise in patients who cannot manage blood glucose levels effectively through lifestyle changes alone.

   • It may be prescribed when diet, exercise, and weight loss are insufficient to control blood glucose levels.

2. As part of combination therapy:

   • Zebet may be used in combination with other oral antidiabetic agents (such as metformin or pioglitazone) if monotherapy is not sufficient.

   • It may also be used in combination with insulin in certain cases, where insulin therapy alone is not enough to maintain adequate blood sugar control.

Dosage and Administration:

For Adults (Type 2 Diabetes):

• Initial dose: The usual starting dose is 40 mg to 80 mg once daily, taken with breakfast.

• Maintenance dose: The dosage may be increased gradually based on blood sugar levels, typically up to 320 mg per day in divided doses.

• Maximum dose: 320 mg per day (divided into two doses if needed).

Administration:

• Oral use only: The tablet should be taken whole with a glass of water.

• It is usually recommended to take Zebet with the first main meal of the day (typically breakfast) to minimize the risk of hypoglycemia (low blood sugar).

• The dose should be individualized depending on the patient’s response and blood glucose levels.

Side Effects:

Like all medications, Zebet (Gliclazide) can cause side effects. Some of the common and less common side effects include:

Common Side Effects:

• Hypoglycemia (low blood sugar): Symptoms may include sweating, shaking, dizziness, fast heartbeat, and confusion.

• Nausea or vomiting.

• Headache.

• Dizziness.

• Weight gain (can occur in some patients when used with other antidiabetic agents).

• Abdominal discomfort or constipation.

• Skin rash.

Serious Side Effects:

• Severe Hypoglycemia: This can result in loss of consciousness or seizures, and requires immediate medical attention.

• Liver Dysfunction: Symptoms may include yellowing of the skin or eyes (jaundice), dark urine, and upper abdominal pain.

• Allergic Reactions: Swelling of the face, lips, throat, or tongue, difficulty breathing, severe rash, or itching.

• Blood disorders: Rare cases of hemolytic anemia, leukopenia, or thrombocytopenia (low white blood cell or platelet count).

Contraindications:

Zebet (Gliclazide) should not be used in the following conditions:

1. Hypersensitivity to Gliclazide or other sulfonylureas: Patients who have a known allergy to gliclazide, sulfonylureas, or any of the excipients in the formulation should avoid using this medication.

2. Type 1 Diabetes Mellitus (Insulin-dependent diabetes): Gliclazide is ineffective for controlling blood sugar in type 1 diabetes, as these patients do not produce insulin.

3. Severe Hepatic Impairment: In patients with significant liver disease, the ability to metabolize gliclazide may be compromised, increasing the risk of hypoglycemia.

4. Severe Renal Impairment: Gliclazide is primarily metabolized by the liver and excreted by the kidneys. In patients with severe kidney dysfunction, the medication may accumulate in the body, leading to an increased risk of side effects.

5. Diabetic Ketoacidosis: Gliclazide is not suitable for use in diabetic ketoacidosis, a serious complication of diabetes that requires urgent medical treatment with insulin.

6. Pregnancy and Breastfeeding: Zebet is not recommended during pregnancy or breastfeeding. If a woman becomes pregnant while using this medication, an alternative treatment should be considered.

7. Alcohol Consumption: Excessive alcohol intake may increase the risk of hypoglycemia and should be avoided during treatment with gliclazide.

Precautions:

• Hypoglycemia Risk: Gliclazide can cause low blood sugar, particularly if meals are missed, after strenuous exercise, or when combined with other medications that lower blood sugar. Patients should be educated on recognizing the symptoms of hypoglycemia and how to manage it (e.g., consuming glucose).

• Renal or Hepatic Impairment: Dose adjustments may be required in patients with mild to moderate renal or hepatic dysfunction. Regular monitoring of liver and kidney function is advised.

• Elderly Patients: Older patients may be at increased risk of developing side effects, particularly hypoglycemia, and may require careful dose adjustments.

• Pregnancy and Breastfeeding: Zebet is not recommended during pregnancy due to potential harm to the fetus. If pregnancy is planned or occurs, an alternative medication should be used. It is also excreted in breast milk, so breastfeeding should be avoided.

Drug Interactions:

1. Other Antidiabetic Agents: Combining Zebet with other oral hypoglycemic agents or insulin may increase the risk of hypoglycemia. Dose adjustments may be necessary.

2. Beta-blockers: These can mask the symptoms of hypoglycemia (e.g., shaking, sweating) and may increase the severity of hypoglycemic episodes.

3. Corticosteroids: Medications like prednisolone can raise blood sugar levels, potentially reducing the effectiveness of gliclazide.

4. Anticoagulants: Warfarin and other blood thinners may interact with gliclazide and alter blood clotting, requiring closer monitoring of coagulation parameters.

5. Alcohol: Alcohol can enhance the blood sugar-lowering effects of gliclazide and may increase the risk of hypoglycemia.

Overdose:

Symptoms of overdose may include:

• Severe Hypoglycemia (dizziness, confusion, sweating, and trembling).

• Loss of consciousness or seizures.

Management of Overdose:

• Immediate treatment: If an overdose occurs and symptoms of hypoglycemia are present, consume glucose immediately. If unconscious, medical assistance should be sought immediately.

• Intravenous glucose or glucagon may be required in severe cases.

Conclusion:

Zebet 80mg (Gliclazide) is an effective oral medication for controlling blood sugar levels in type 2 diabetes mellitus. It works by stimulating insulin release and improving tissue sensitivity to insulin. Regular monitoring of blood glucose levels, diet, and lifestyle modifications are important for optimal management of diabetes. It should be used with caution in patients with renal or hepatic impairment and is contraindicated in type 1 diabetes and other conditions listed above. Always follow the prescribed dosage and consult a healthcare provider before making any changes to the treatment regimen.