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Bambang Pharmaceutical Depot Inc.

Hyoscine N Butylbromide (Gasmodic) 20mg/ml Solution for Injection (IM/IV) Anticholinergic 1ml x 10 Ampoules

Hyoscine N Butylbromide (Gasmodic) 20mg/ml Solution for Injection (IM/IV) Anticholinergic 1ml x 10 Ampoules

Regular price ₱288.00
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Certainly! Below is the detailed information for Hyoscine N-Butylbromide (Gasmodic) 20mg/ml Solution for Injection (IM/IV) Anticholinergic 1ml x 10 Ampoules:

Product Description:

Hyoscine N-Butylbromide (Gasmodic) is a 20mg/ml solution for injection, commonly used as an anticholinergic agent to treat smooth muscle spasms, especially in the gastrointestinal and urinary tracts. It is formulated for intramuscular (IM) or intravenous (IV) injection and is available in 1ml ampoules, with each ampoule containing 20mg of Hyoscine N-Butylbromide.

Hyoscine N-Butylbromide works by inhibiting the action of acetylcholine, a neurotransmitter that normally stimulates the contraction of smooth muscles. By blocking acetylcholine, it reduces muscle spasms and alleviates pain associated with spasmodic conditions. It is commonly used for the symptomatic relief of gastrointestinal and urological disorders.

Indications:

Hyoscine N-Butylbromide (Gasmodic) is primarily used for:

  • Abdominal pain and discomfort: Due to spasm of smooth muscles, such as in irritable bowel syndrome (IBS) or functional gastrointestinal disorders.

  • Urological disorders: For relieving bladder spasms, especially in conditions such as cystitis, prostatitis, or following bladder surgery.

  • Gastrointestinal Disorders: To treat conditions that involve spasms of the gastrointestinal tract, such as colic or gastroenteritis.

  • Spasms due to biliary tract disease or following certain diagnostic procedures (e.g., endoscopy).

  • In some cases, it can also be used during procedures involving the intestines or the urinary system to reduce spasm and discomfort.

Dosage:

The typical dosages of Hyoscine N-Butylbromide (Gasmodic) will vary based on the condition being treated, the severity of symptoms, and the patient's medical status. Below are general dosing guidelines:

  • For Gastrointestinal Spasms:

    • Adults and Children over 12 years old: 20mg (1ml) injected intramuscularly or intravenously, repeated every 4-6 hours if necessary. The maximum recommended dose is 100mg (5ml) per day.

  • For Urological Spasms:

    • Adults and Children over 12 years old: 20mg (1ml) injected intramuscularly or intravenously, repeated as needed. The dose can be repeated 3-4 times per day, with a maximum of 100mg per day.

  • For Postoperative Pain or Spasms (i.e., after surgeries involving the gastrointestinal or urological systems):

    • The dosage is generally the same as for gastrointestinal and urological spasms, typically 20mg (1ml) IM/IV, repeated up to 3-4 times per day based on the severity of symptoms and clinical response.

Important Note: The dosage should be adjusted according to the patient's specific needs and responses. It is essential that this medication be administered under the supervision of a healthcare professional, especially in the case of intravenous injections.

Side Effects:

Like any medication, Hyoscine N-Butylbromide (Gasmodic) can cause side effects. Common side effects include:

  • Dry mouth: Due to the anticholinergic effects, which can reduce saliva production.

  • Blurred vision: As a result of pupil dilation (mydriasis), which is common with anticholinergic drugs.

  • Dizziness or drowsiness: This is possible, particularly with the intravenous form.

  • Constipation: Can occur due to reduced gastrointestinal motility.

  • Urinary retention: Difficulty urinating can happen in some cases, particularly in older adults.

Less common but more severe side effects include:

  • Tachycardia (rapid heartbeat): Due to the inhibition of parasympathetic nervous function.

  • Confusion or hallucinations: These may be more likely in elderly patients.

  • Severe allergic reactions: Such as difficulty breathing, swelling of the face or throat, and rash (rare but serious).

  • Paralytic ileus (intestinal paralysis): Although rare, this can occur with the overuse of anticholinergic medications.

If any serious side effects occur, immediate medical attention should be sought.

Contraindications:

Hyoscine N-Butylbromide (Gasmodic) should not be used in the following conditions:

  • Hypersensitivity to Hyoscine N-Butylbromide or any of the excipients in the product. An allergic reaction to any part of the formulation would contraindicate its use.

  • Glaucoma: Especially narrow-angle glaucoma, as the anticholinergic effect can increase intraocular pressure and worsen the condition.

  • Myasthenia Gravis: A condition in which the body's muscles become weak. Hyoscine N-Butylbromide can exacerbate muscle weakness.

  • Severe Ulcerative Colitis or Megacolon: Since the drug can worsen gastrointestinal motility issues, it should be avoided in patients with these conditions.

  • Urinary retention: In patients who are prone to urinary retention (e.g., those with prostatic hypertrophy or bladder obstruction).

  • Severe Heart Disease: Patients with certain types of heart disease, including tachyarrhythmias, should avoid this medication due to its potential to exacerbate heart rhythm issues.

  • Severe Hepatic or Renal Impairment: Because of the potential for accumulation of the drug, it is contraindicated in patients with severe liver or kidney dysfunction.

Precautions:

  • Elderly Patients: Older adults are more susceptible to the side effects of anticholinergics, such as confusion, hallucinations, and difficulty urinating. Dosage should be adjusted accordingly, and careful monitoring is needed.

  • Renal and Hepatic Impairment: Caution is required in patients with mild to moderate liver or kidney disease. The drug may need to be dosed carefully, as accumulation could lead to toxicity.

  • Pregnancy and Breastfeeding: The safety of Hyoscine N-Butylbromide in pregnancy and breastfeeding has not been well-established. It should be used only if the potential benefit justifies the potential risk to the fetus or infant. Always consult with a healthcare provider before using the medication during pregnancy or lactation.

  • Intestinal Obstruction: Use cautiously in patients with bowel obstruction or other severe gastrointestinal conditions.

Drug Interactions:

  • Other Anticholinergic Drugs: When combined with other medications that have anticholinergic properties (such as certain antihistamines, tricyclic antidepressants, and some antipsychotic medications), the side effects, particularly dry mouth, urinary retention, and constipation, can be exacerbated.

  • Antihypertensive Medications: Hyoscine N-Butylbromide may potentiate the effects of blood pressure-lowering drugs, so monitoring is required, especially in patients who are on antihypertensive therapy.

  • CNS Depressants: The sedative effects of medications like benzodiazepines or alcohol may be enhanced when combined with hyoscine, increasing the risk of dizziness and drowsiness.


Summary:

Hyoscine N-Butylbromide (Gasmodic) is an anticholinergic medication used to treat gastrointestinal and urological spasms, providing relief from pain and discomfort. It is commonly administered as a 20mg/ml solution for injection (IM/IV) and is effective in conditions such as irritable bowel syndrome, bladder spasms, and postoperative abdominal pain. The usual dosage is 1ml (20mg), with potential repeat doses depending on the patient's response.

While generally safe, this medication can cause side effects such as dry mouth, blurred vision, and dizziness. It should be avoided in patients with glaucoma, myasthenia gravis, severe gastrointestinal issues, and certain other conditions. Always consult with a healthcare provider before using this medication to ensure it is appropriate for your specific condition.

For further personalized advice, please consult a healthcare professional.

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