Bambang Pharmaceutical Depot Inc.
Metoprolol Tartate (Proled) 50mg Tablet 100's
Metoprolol Tartate (Proled) 50mg Tablet 100's
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Product Description:
Metoprolol Tartrate (Proled) 50mg tablets are a medication in the beta-blocker class, primarily used to manage cardiovascular conditions. Each tablet contains 50 mg of Metoprolol Tartrate, which works by blocking the action of adrenaline and other similar substances on the heart and blood vessels. This leads to a reduction in heart rate, blood pressure, and the workload on the heart, improving overall cardiovascular health. Proled 50mg Tablets come in a pack of 100 tablets, providing a cost-effective solution for the long-term management of conditions like hypertension, angina, and other heart-related issues.
Indications:
Metoprolol Tartrate (Proled) is indicated for the treatment of the following conditions:
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Hypertension (High Blood Pressure):
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Proled 50mg helps lower blood pressure by decreasing the heart rate and dilating blood vessels, which reduces the strain on the heart and decreases the risk of heart-related complications such as stroke and heart attack.
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Angina Pectoris (Chest Pain):
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Used in the prevention and treatment of angina, which occurs due to reduced blood flow to the heart. By reducing the heart's demand for oxygen, Metoprolol helps to prevent episodes of chest pain.
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Acute Myocardial Infarction (Heart Attack):
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Metoprolol Tartrate is used to reduce mortality and the risk of complications following an acute heart attack by slowing the heart rate and reducing the heart's oxygen consumption.
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Chronic Heart Failure:
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In patients with chronic heart failure, Metoprolol helps improve heart function and reduces the risk of hospitalization by slowing the progression of the disease.
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Arrhythmias (Irregular Heartbeats):
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Proled is used to control arrhythmias, including atrial fibrillation and ventricular arrhythmias, by controlling heart rate and rhythm.
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Dosage:
The dosage of Metoprolol Tartrate (Proled) should be individualized depending on the specific condition being treated. Below are general dosage recommendations:
For Hypertension (High Blood Pressure):
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Initial Dose: 50 mg once daily.
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Maintenance Dose: The dose may be gradually increased depending on the patient's response, with typical doses ranging from 100 mg to 200 mg daily, either as a single dose or divided into two doses.
For Angina Pectoris (Chest Pain):
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Initial Dose: 50 mg twice daily.
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Maintenance Dose: The dose may be adjusted based on the patient's condition, with typical maintenance doses ranging from 100 mg to 200 mg daily.
For Acute Myocardial Infarction (Heart Attack):
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Initial Dose: An intravenous (IV) dose may be given during the acute phase of heart attack, followed by 50 mg orally twice daily once the patient is stable.
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Maintenance Dose: The maintenance dose typically ranges from 100 mg to 200 mg daily, depending on the patient's condition.
For Chronic Heart Failure:
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Starting Dose: 12.5 mg to 25 mg daily, with the dose gradually increased based on tolerance and clinical response. The target dose may be 100 mg to 200 mg daily.
For Arrhythmias:
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Initial Dose: 50 mg twice daily, with adjustments based on the patient's response and heart rate control.
Administration:
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The tablets can be taken with or without food.
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It is important to take Proled at the same time every day to help remember the dose.
Side Effects:
Although Metoprolol Tartrate (Proled) is generally well tolerated, some people may experience side effects. These can include:
Common Side Effects:
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Fatigue or tiredness.
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Dizziness or lightheadedness, especially when standing up quickly.
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Bradycardia (slow heart rate), which may cause fatigue, dizziness, or fainting.
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Cold hands and feet.
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Nausea or vomiting.
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Shortness of breath or wheezing (especially in patients with asthma or COPD).
Serious Side Effects (Less common, but can occur):
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Severe Bradycardia: Heart rate can drop below 40-45 beats per minute, potentially causing dizziness, fainting, or more severe symptoms.
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Severe hypotension (low blood pressure), causing dizziness, confusion, or fainting.
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Heart failure symptoms worsening, such as increased shortness of breath, fatigue, or swelling of the legs or ankles.
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Severe allergic reactions: Symptoms like rash, itching, swelling, or difficulty breathing.
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Bronchospasm (tightening of the airways) in patients with asthma or COPD.
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Liver dysfunction: Symptoms may include yellowing of the skin or eyes (jaundice), dark urine, or pain in the upper right abdomen.
If any of these serious side effects occur, immediate medical attention should be sought.
Contraindications:
Metoprolol Tartrate (Proled) should be avoided in the following conditions:
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Hypersensitivity: Known allergy to Metoprolol or any of the components of the medication.
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Severe Bradycardia: Metoprolol should not be used if the heart rate is less than 45-50 beats per minute.
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Heart Block (2nd or 3rd degree): Proled is contraindicated in patients with significant atrioventricular (AV) block unless they have a pacemaker.
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Severe Heart Failure: It is contraindicated in patients with acute decompensated heart failure or those with unstable heart failure symptoms unless the patient is closely monitored.
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Asthma or Chronic Obstructive Pulmonary Disease (COPD): Metoprolol may cause bronchoconstriction (narrowing of the airways) and should be avoided in patients with asthma or severe COPD.
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Severe Hypotension (Low Blood Pressure): Metoprolol should not be used in patients with significantly low blood pressure.
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Pheochromocytoma: This condition (a tumor of the adrenal glands) requires prior treatment with an alpha-blocker before the use of a beta-blocker like Metoprolol.
Precautions:
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Pregnancy: Metoprolol Tartrate is classified as Category C during pregnancy. It should only be used if the benefits outweigh the risks, and the fetus is closely monitored.
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Breastfeeding: Metoprolol passes into breast milk in small amounts. It should be used cautiously while breastfeeding.
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Renal and Hepatic Impairment: Metoprolol is metabolized in the liver, and it is excreted by the kidneys. Therefore, caution is needed in patients with kidney or liver impairment.
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Diabetes: Metoprolol may mask some symptoms of hypoglycemia (low blood sugar), such as tachycardia, so diabetic patients should monitor their blood sugar carefully.
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Discontinuation: Metoprolol should not be discontinued abruptly as this may lead to rebound hypertension or worsening angina. Gradual tapering under the supervision of a healthcare provider is recommended.
Drug Interactions:
Metoprolol Tartrate (Proled) may interact with the following medications:
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Calcium Channel Blockers (e.g., Verapamil, Diltiazem): Concomitant use can cause severe bradycardia and heart block.
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Clonidine: Abrupt cessation of Clonidine while taking Metoprolol may cause a hypertensive crisis (severe increase in blood pressure). Clonidine should be tapered gradually.
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Digoxin: The combination of Metoprolol and Digoxin may increase the risk of bradycardia (slow heart rate).
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NSAIDs: Nonsteroidal anti-inflammatory drugs (NSAIDs) may reduce the blood pressure-lowering effect of Metoprolol.
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Insulin and Oral Hypoglycemic Agents: Since Metoprolol can mask symptoms of hypoglycemia, diabetic patients should monitor their blood sugar levels carefully when on this medication.
Conclusion:
Metoprolol Tartrate (Proled) 50mg tablets are a beta-blocker medication used to treat hypertension, angina, heart failure, and arrhythmias. While effective in treating these conditions, it should be used cautiously in patients with certain health issues such as asthma, severe bradycardia, and liver or kidney impairment. Always follow the prescribed dosage, and contact your healthcare provider if you experience any unusual side effects.
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