Pioglitazone (Zeal) 30mg Thiazolidinedione Tablet 28's

Generic Name: Pioglitazone

Brand Name: Zeal

Strength: 30mg

Form: Tablet

Manufacturer:

Imported and Distributed by:

Classification: Thiazolidinedione

Indication/Uses:

Pioglitazone, marketed as Zeal in a 30mg tablet form, is a thiazolidinedione class medication used primarily in the management of type 2 diabetes mellitus. Here are the main indications and uses:

Indications and Uses

1. Type 2 Diabetes Mellitus:
   • Blood Glucose Control: Used to improve glycemic control in adults with type 2 diabetes mellitus. It helps lower blood glucose levels by increasing the body's sensitivity to insulin.
   • Combination Therapy: Often used in combination with other antidiabetic agents, such as metformin, sulfonylureas, or insulin, when these agents alone do not provide adequate blood glucose control.

Mechanism of Action

• Insulin Sensitizer: Pioglitazone works by activating peroxisome proliferator-activated receptor gamma (PPAR-γ), a type of nuclear receptor. This activation enhances insulin sensitivity in muscle and fat tissues, leading to improved glucose uptake and lower blood sugar levels.

Dosage and Administration

• Typical Dosage: The usual starting dose is 15mg to 30mg once daily. The dose may be adjusted based on the patient's glycemic response and tolerance.
• Administration: The tablets should be taken orally, with or without food. It is important to follow the healthcare provider's instructions regarding dosage and administration.

Precautions

• Heart Failure: Use with caution in patients with heart failure or a history of heart disease, as thiazolidinediones can cause or exacerbate heart failure.
• Liver Function: Monitor liver function regularly, as pioglitazone can cause hepatotoxicity. Discontinue use if significant liver enzyme elevations occur.
• Bone Health: May increase the risk of bone fractures. Monitor bone health, especially in postmenopausal women and elderly patients.

Monitoring

• Blood Glucose Levels: Regular monitoring of blood glucose levels is necessary to assess the effectiveness of the treatment.
• Liver Enzymes: Routine checks of liver function tests to monitor for any signs of liver damage.

Pioglitazone (Zeal) is an effective medication for managing type 2 diabetes, especially when used as part of a comprehensive treatment plan that includes diet, exercise, and other antidiabetic medications. Proper use and regular monitoring are essential for achieving optimal outcomes and minimizing potential risks.