Piperacillin + Tazobactam (Pipetasaph 4.5) 4g/500mg Powder for Injection for IV Infusion Vial 1's

Generic Name: Piperacillin + Tazobactam

Brand Name: Pipetasaph 4.5

Strength: 4g / 500mg

Form: Vial

Manufacturer:

Imported and Distributed by:

Classification: Antibacterial

Indication/Uses:

Piperacillin + Tazobactam, marketed as Pipetasaph 4.5, is a combination antibiotic medication available in a 4g/500mg powder for intravenous (IV) infusion. This combination includes piperacillin, a broad-spectrum penicillin antibiotic, and tazobactam, a β-lactamase inhibitor. Here are the main indications and uses:

Indications and Uses

1. Complicated Intra-Abdominal Infections:

   • Infections: Used to treat complicated infections in the abdominal area, such as peritonitis or intra-abdominal abscesses, where mixed bacterial infections are common.

2. Complicated Skin and Soft Tissue Infections:

   • Infections: Effective for treating severe skin and soft tissue infections, including those caused by both aerobic and anaerobic bacteria.

3. Complicated Urinary Tract Infections (UTIs):

   • Infections: Used for severe or complicated UTIs, particularly when caused by resistant strains of bacteria.

4. Complicated Pneumonia:

   • Infections: Treatment of complicated pneumonia, including hospital-acquired pneumonia, when caused by susceptible bacteria.

5. Febrile Neutropenia:

   • Infections: Used in the treatment of febrile neutropenia (fever in patients with low white blood cell counts) often seen in cancer patients undergoing chemotherapy.

Mechanism of Action

• Piperacillin: A broad-spectrum penicillin antibiotic that inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs). This leads to bacterial cell death.
• Tazobactam: A β-lactamase inhibitor that protects piperacillin from being broken down by β-lactamase enzymes produced by some bacteria, thereby extending the spectrum of piperacillin’s activity.

Dosage and Administration

• Typical Dosage: The dosage is typically 3.375g to 4.5g administered every 6 to 8 hours, depending on the severity of the infection and the patient's renal function. The dosage may vary based on the specific infection being treated and the patient’s condition.
• Administration: The powder is reconstituted with a suitable diluent and administered as an IV infusion over a period of 30 minutes to 1 hour.

Precautions

• Allergic Reactions: Use with caution in patients with a history of hypersensitivity to penicillins or β-lactam antibiotics.
• Renal Function: Dosage adjustments may be necessary for patients with renal impairment, as the drug is primarily excreted through the kidneys.
• Superinfection: Monitor for signs of superinfection, such as fungal infections, which can occur with prolonged use of broad-spectrum antibiotics.