Rifampicin (Famtricin Forte) 200mg / 5ml Suspension 60ml

Generic Name: Rifampicin

Brand Name: Famtricin Forte

Strength: 200mg / 5ml

Form: Suspension

Manufacturer:

Imported and Distributed by:

Classification: Antituberculosis

Indication/Uses:

Rifampicin (Famtricin Forte) 200mg/5ml Suspension is an antibiotic used primarily for the treatment of bacterial infections. Here are the primary indications and uses for this medication:

Indications and Uses

1. Tuberculosis (TB):

   • First-Line Treatment: Rifampicin is a key component of the multi-drug regimen used to treat active tuberculosis (TB) caused by Mycobacterium tuberculosis. It is often used in combination with other antitubercular drugs such as isoniazid, pyrazinamide, and ethambutol.

2. Leprosy:

   • Treatment: Used in combination with other medications for the treatment of leprosy (Hansen’s disease), which is caused by Mycobacterium leprae.

3. Other Mycobacterial Infections:

   • Non-Tuberculous Mycobacterial Infections: Rifampicin can also be used for treating infections caused by non-tuberculous mycobacteria (NTM), including certain types of atypical mycobacterial infections.

4. Prophylaxis:

   • Meningococcal Disease: Rifampicin is used for prophylaxis in individuals who have been in close contact with someone diagnosed with meningococcal disease (caused by Neisseria meningitidis), to prevent the spread of infection.

5. Staphylococcal Infections:

   • Serious Infections: Rifampicin may be used in combination with other antibiotics for the treatment of serious staphylococcal infections, including those caused by Staphylococcus aureus, particularly in cases where the bacteria are resistant to other antibiotics.

Mechanism of Action

• Inhibition of Bacterial RNA Synthesis: Rifampicin works by inhibiting bacterial RNA polymerase, an enzyme essential for bacterial RNA synthesis. This action prevents bacteria from reproducing and ultimately leads to their death.

Dosage and Administration

• Typical Dosage: For the suspension form, the dosage will vary based on the condition being treated, the patient’s age, weight, and overall health. The usual adult dose for tuberculosis is 10 mg/kg to 20 mg/kg of body weight, typically administered once daily.
• Administration: Shake the suspension well before use. Measure the dose using an appropriate measuring device and take it orally. The exact dosage and duration of treatment should be determined by a healthcare provider.

Precautions

• Liver Function: Monitor liver function regularly, as rifampicin can cause liver damage or exacerbate pre-existing liver conditions.
• Drug Interactions: Rifampicin can interact with many other medications, including oral contraceptives, anticoagulants, and certain antiepileptics. Inform your healthcare provider of all medications you are taking.
• Adherence: Adherence to the full course of treatment is crucial to prevent the development of drug-resistant strains of bacteria.

Side Effects

• Common: Gastrointestinal disturbances such as nausea, vomiting, and diarrhea; discoloration of bodily fluids (e.g., urine, sweat) to red or orange.
• Serious: Liver toxicity, hypersensitivity reactions, and rare but serious conditions such as blood disorders (e.g., thrombocytopenia, leukopenia).

Monitoring

• Regular Check-Ups: Regular follow-ups are necessary to monitor the effectiveness of the treatment and to check for potential side effects, especially liver function.
• Adherence to Therapy: Ensure adherence to the prescribed regimen to avoid treatment failure and resistance.

Rifampicin (Famtricin Forte) 200mg/5ml Suspension is a vital medication in treating and preventing various bacterial infections, particularly tuberculosis and leprosy. Proper dosage, monitoring for side effects, and adherence to treatment are essential for effective therapy and minimizing potential adverse effects.