Silver Sulfadiazine (Sildiaz) 10mg/g (1% w/w) Topical Antibacterial Cream 1 Tube 20g

Product Description:

Silver Sulfadiazine (Sildiaz) 10mg/g (1% w/w) Topical Antibacterial Cream is a prescription medication used to prevent and treat infections in burns and wounds. It contains silver sulfadiazine, a combination of silver and sulfadiazine, which works as an antimicrobial agent. The cream is applied topically to the skin, where it helps inhibit bacterial growth, thus preventing infection and promoting healing. Silver Sulfadiazine is especially effective against a broad range of bacteria and is commonly used in the care of second and third-degree burns, cuts, and other skin lesions.

This 1% w/w formulation is typically available in a 20g tube, making it easy to apply and convenient for use in both medical settings and at home under professional supervision.

Indications:

Silver Sulfadiazine (Sildiaz) 10mg/g (1% w/w) Topical Antibacterial Cream is primarily indicated for:

• Burns: To prevent and treat bacterial infections in second and third-degree burns.

• Wounds: To prevent infection in minor cuts, scrapes, and abrasions.

• Skin Grafts: To aid in the prevention of infection in skin grafts and prevent infections in areas where skin is being repaired or replaced.

• Ulcers: Can be used for certain types of skin ulcers to help prevent bacterial infections and promote healing.

Dosages:

• Adults and Children:

  • Apply a thin layer of Silver Sulfadiazine (Sildiaz) 10mg/g cream directly to the affected area once or twice daily, or as directed by your healthcare provider.

  • The cream should be applied to clean and dry skin, covering the burn or wound with a thin film.

  • For severe burns, more frequent application may be needed, but this should be determined by a healthcare professional based on the severity of the burn.

  • Duration of treatment varies depending on the size and type of the wound or burn, but treatment usually lasts until the wound or burn is sufficiently healed or the risk of infection is minimal.

• Special Considerations: In some cases, depending on the size of the area being treated and the condition of the patient, a healthcare provider may recommend more frequent applications or special care instructions.

Side Effects:

While Silver Sulfadiazine (Sildiaz) 10mg/g is generally well-tolerated, some individuals may experience side effects, including:

• Local skin reactions:

  • Burning, itching, or stinging at the application site.

  • Dryness or peeling of the skin.

  • Redness or rash at the site of application.

• Allergic Reactions:

  • Rarely, a person may develop a rash, itching, or swelling (especially of the face/tongue/throat), severe dizziness, or trouble breathing, which could be signs of an allergic reaction.

• Systemic Side Effects (uncommon with topical use, but may occur):

  • If used over large areas of the body, especially if the patient has impaired skin or large burns, silver toxicity can occur, leading to symptoms such as blue-gray skin discoloration (argyria).

  • Blood disorders: Rarely, use of silver sulfadiazine may result in changes to blood counts, such as low white blood cell count (leukopenia), which can increase the risk of infection.

  • Renal or liver toxicity: In rare cases, if used extensively, silver sulfadiazine can affect the kidneys or liver, particularly in patients with pre-existing conditions affecting these organs.

If any of these side effects occur, it is important to contact a healthcare provider.

Contraindications:

Silver Sulfadiazine (Sildiaz) 10mg/g cream should not be used in the following situations:

• Hypersensitivity: Individuals who are allergic to silver sulfadiazine, sulfadiazine, or any other component of the cream should avoid using this medication.

• Pregnancy: Silver Sulfadiazine should be used cautiously in pregnant women, especially during the third trimester, as the drug can potentially cross the placenta. It is best used under the guidance of a healthcare provider, and only if the benefit outweighs the risk.

• Newborns and infants: Silver sulfadiazine is contraindicated in neonates and infants younger than 2 months due to the risk of kernicterus (a type of brain damage caused by high levels of bilirubin), as sulfadiazine can displace bilirubin from albumin and increase bilirubin levels.

• G6PD Deficiency: People with glucose-6-phosphate dehydrogenase (G6PD) deficiency may be at increased risk for hemolytic anemia when using silver sulfadiazine, as this condition can cause red blood cells to break down more easily under certain stressors, including certain medications.

• Severe renal or hepatic impairment: Patients with significant kidney or liver problems may not tolerate silver sulfadiazine well, particularly if large areas of the body are treated, as this could lead to systemic absorption.

Notes:

• Proper application: Apply Silver Sulfadiazine to clean, dry skin. Wash hands before and after application, and ensure the treatment area is free of dirt, debris, or other contaminants before applying the cream.

• Infection control: Although Silver Sulfadiazine is an effective antimicrobial, it should be used as part of a comprehensive wound care plan that includes proper wound cleaning and dressing.

• Monitoring for systemic effects: If treating extensive burns or large wounds, it is important for the healthcare provider to monitor the patient for signs of silver toxicity, hematological changes, or renal and liver dysfunction.

• Avoid use near eyes and mucous membranes: Do not apply Silver Sulfadiazine to the eyes, mouth, or mucous membranes. If accidental exposure occurs, rinse thoroughly with water.

Consult a healthcare provider for detailed instructions regarding the proper use of Silver Sulfadiazine (Sildiaz) 10mg/g cream, as they will consider your specific medical needs and ensure the medication is applied correctly to prevent infection and promote healing.