Generic Name: Pregabalin

Brand Name: Pregabasaph 75

Strength: 75mg

Form: Capsule

Manufacturer: Sapphire Lifescniences, PVT. LTD.

Imported and Distributed by: Nelpa Lifesciences, Inc.

Classification: Antiepileptic

Indication/Uses:

Pregabalin (Pregabasaph 75) 75mg Capsules are used primarily as an antiepileptic medication and for various other therapeutic indications. Here are the main indications and uses:

Indications and Uses

1. Epilepsy:

   • Partial Seizures: Used as an adjunctive therapy for the treatment of partial seizures in adults with epilepsy. It helps to control seizures that do not respond adequately to other medications.

2. Neuropathic Pain:

   • Diabetic Peripheral Neuropathy: Treats neuropathic pain associated with diabetic peripheral neuropathy, a type of nerve pain resulting from diabetes.
   • Postherpetic Neuralgia: Used for the management of postherpetic neuralgia, a nerve pain that occurs after an episode of shingles.

3. Fibromyalgia:

   • Fibromyalgia: Provides relief for fibromyalgia, a condition characterized by widespread muscle pain, fatigue, and tenderness.

4. Generalized Anxiety Disorder:

   • Anxiety: In some cases, pregabalin is used off-label for the treatment of generalized anxiety disorder (GAD), though it is not officially approved for this use in all regions.

Mechanism of Action

• Calcium Channel Modulation: Pregabalin binds to the α2δ subunit of voltage-gated calcium channels in the central nervous system. This reduces the release of neurotransmitters involved in pain and seizure generation, thus helping to control symptoms.

Dosage and Administration

• Typical Dosage: Dosage depends on the condition being treated. For neuropathic pain and fibromyalgia, it is often started at a lower dose and gradually increased based on efficacy and tolerance. For epilepsy, it is used as an add-on therapy.
• Administration: Capsules should be taken orally with or without food. The dosage should be taken as prescribed, and the capsules should be swallowed whole.

Precautions

• Drowsiness: Pregabalin may cause drowsiness, dizziness, or impaired concentration, which can affect the ability to drive or operate machinery.
• Dependence: Use with caution in patients with a history of substance abuse, as there is a potential for misuse.
• Withdrawal: Do not abruptly stop taking pregabalin without consulting a healthcare provider, as discontinuation can lead to withdrawal symptoms.

Side Effects

• Common: Drowsiness, dizziness, dry mouth, edema (swelling), and weight gain.
• Serious: Rare but serious side effects may include allergic reactions, mood changes, suicidal thoughts, and severe drowsiness.

Monitoring

• Regular Follow-Ups: Regular medical follow-ups are necessary to assess effectiveness, adjust dosage, and monitor for side effects.
• Mental Health: Monitor for any mood changes or signs of depression, especially in patients with a history of mood disorders.

Pregabalin (Pregabasaph 75) 75mg Capsules are used for managing epilepsy, neuropathic pain, fibromyalgia, and sometimes anxiety. Proper dosage, administration, and monitoring are crucial to ensure efficacy and safety while minimizing potential side effects.