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Bambang Pharmaceutical Depot Inc.

Amlodipine Besilate (Eodipine 10) 10mg Tablet 100's

Amlodipine Besilate (Eodipine 10) 10mg Tablet 100's

Regular price ₱132.00
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Certainly! Here is the detailed information for Amlodipine Besilate (Eodipine 10) 10mg Tablet 100's:


Product Description:

Amlodipine Besilate (Eodipine 10) is a calcium channel blocker (CCB) used to treat high blood pressure (hypertension) and certain types of angina (chest pain). Amlodipine works by relaxing the blood vessels, improving blood flow, and reducing the workload on the heart. The medication comes in 10mg tablets, with each pack containing 100 tablets.

As a dihydropyridine calcium channel blocker, Amlodipine specifically acts on the smooth muscle of the blood vessels, leading to vasodilation (widening of blood vessels), which helps to lower blood pressure and relieve the symptoms of angina.

Indications:

Amlodipine Besilate (Eodipine 10) is indicated for the following conditions:

  1. Hypertension (High Blood Pressure):

    • Amlodipine is used to lower elevated blood pressure, which helps prevent complications such as stroke, heart attack, and kidney damage.

  2. Angina Pectoris:

    • Amlodipine is used to prevent and treat stable angina (chest pain caused by restricted blood flow to the heart). It also helps prevent vasospastic angina (Prinzmetal's angina), a condition where the blood vessels in the heart temporarily constrict.

  3. Coronary Artery Disease:

    • It can also be used to reduce symptoms and improve exercise tolerance in patients with coronary artery disease (CAD).

  4. Off-label Uses:

    • In some cases, Amlodipine may be used for heart failure in combination with other medications, although this is not a primary indication.

Dosage:

The recommended dosage for Amlodipine Besilate (Eodipine 10) depends on the condition being treated and individual patient factors:

  • Hypertension (High Blood Pressure):

    • The usual starting dose is 5mg once daily. Depending on the patient's response, the dose may be increased to 10mg once daily.

  • Angina Pectoris (Chest Pain):

    • The usual dose is 5mg once daily. In some cases, the dose may be increased to 10mg once daily for better control of symptoms.

  • Patients with Liver Impairment:

    • In patients with mild to moderate liver impairment, the starting dose is usually 2.5mg once daily, and the dose can be gradually increased.

  • Elderly or Patients with Renal Impairment:

    • Amlodipine is not significantly cleared by the kidneys, so dose adjustments for renal impairment are generally not required. However, caution should be exercised in elderly patients, starting at 2.5mg to 5mg once daily.

Side Effects:

Like all medications, Amlodipine Besilate (Eodipine 10) may cause side effects, though not everyone experiences them. Common and serious side effects include:

Common Side Effects:

  • Headache.

  • Dizziness or lightheadedness.

  • Swelling (edema) of the ankles or feet due to fluid retention.

  • Flushing or a warm sensation.

  • Fatigue or tiredness.

  • Nausea or stomach discomfort.

Serious Side Effects:

  • Severe allergic reactions: Symptoms may include swelling of the face, lips, tongue, or throat, difficulty breathing, or rash.

  • Heart Palpitations (Tachycardia): An unusually fast heart rate may occur.

  • Severe dizziness or fainting: May indicate low blood pressure.

  • Chest pain (angina): In rare cases, Amlodipine may worsen chest pain, particularly in patients with severe coronary artery disease.

  • Liver dysfunction: Symptoms may include yellowing of the skin or eyes (jaundice), dark urine, or persistent abdominal pain.

If you experience any of the above serious side effects, seek medical attention immediately.

Contraindications:

Amlodipine Besilate (Eodipine 10) is contraindicated in the following conditions:

  • Hypersensitivity to Amlodipine or other calcium channel blockers: If you are allergic to Amlodipine or any of its components, you should not take this medication.

  • Severe hypotension (low blood pressure): Amlodipine can further lower blood pressure, so it is contraindicated in individuals with severely low blood pressure.

  • Shock or collapse (including cardiogenic shock): Use of Amlodipine in patients with these conditions can worsen symptoms.

  • Severe hepatic impairment: In patients with severe liver disease, Amlodipine may cause increased drug levels, leading to toxicity. The dose should be adjusted or avoided depending on the severity of liver disease.

  • Pregnancy (Category C): Although there is limited evidence, Amlodipine should be used during pregnancy only if the potential benefits outweigh the risks. It is generally advised to avoid using Amlodipine in the first trimester unless absolutely necessary.

  • Breastfeeding: Amlodipine passes into breast milk in small amounts. Use caution and consult with a healthcare provider before taking it while breastfeeding.

Precautions:

  • Caution in elderly patients: Elderly patients are more likely to experience the side effect of swelling (edema) and should be monitored.

  • Caution in patients with heart failure: Amlodipine can be used cautiously in heart failure patients, but it should not be used as a sole treatment for this condition.

  • Caution with other medications that affect blood pressure: When combined with other medications that lower blood pressure (such as ACE inhibitors, diuretics, or beta-blockers), Amlodipine may result in a more pronounced decrease in blood pressure, increasing the risk of hypotension.

  • Monitor for peripheral edema (swelling): A common side effect of Amlodipine is peripheral edema, especially in patients with pre-existing heart conditions.

Drug Interactions:

Amlodipine (Eodipine 10) can interact with the following medications:

  • Antihypertensive drugs (e.g., ACE inhibitors, ARBs, diuretics, beta-blockers): Combining these medications with Amlodipine may result in an additive effect, lowering blood pressure too much.

  • CYP3A4 inhibitors (e.g., ketoconazole, itraconazole, ritonavir): These can increase the blood levels of Amlodipine, raising the risk of side effects like swelling or dizziness.

  • CYP3A4 inducers (e.g., rifampin, phenytoin, carbamazepine): These drugs may lower the effectiveness of Amlodipine by reducing its blood concentration.

  • Simvastatin: When combined with Amlodipine, the dose of simvastatin should be limited to 20mg daily to reduce the risk of muscle-related side effects.

  • Lithium: Amlodipine can enhance the side effects of lithium, leading to an increased risk of lithium toxicity.

Summary:

Amlodipine Besilate (Eodipine 10) is a calcium channel blocker that is used to treat hypertension and angina by relaxing blood vessels and improving blood flow. The usual dose for adults is 5mg to 10mg once daily, depending on the condition being treated.

Common side effects include headache, dizziness, and swelling of the ankles or feet, while more serious side effects may include severe allergic reactions, low blood pressure, and liver dysfunction. Amlodipine is contraindicated in patients with severe hypotension, severe hepatic impairment, and those with known hypersensitivity to the drug. Caution is recommended when using Amlodipine with other blood pressure-lowering medications or in patients with heart failure.

Always follow your healthcare provider's instructions regarding dosage and administration and inform them about any other medications you are taking to avoid potential interactions.

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