Ampicillin + Sulbactam 1g/500mg Powder For Injection (I.M/I.V) Antibacterial Vials 10's

Generic Name: AMPICILLIN + SULBACTAM

Brand Name: BACTICARE

Strength: 1g/500mg

Form: VIALS

Manufacturer: NORTH CHINA PHARMACEUTICAL CO., LTD. 

Imported and Distributed by: EURO-CARE PRODUCTS PHILIPPINES

Classification: ANTIBACTERIAL

Indication/Uses: 

1. Skin and Soft Tissue Infections

   • Usage: Effective against a wide range of pathogens causing infections in the skin and soft tissues, including cellulitis, abscesses, and wound infections.

2. Respiratory Tract Infections

   • Usage: Used for treating upper and lower respiratory tract infections, such as pneumonia, bronchitis, and sinusitis caused by susceptible organisms.

3. Intra-Abdominal Infections

   • Usage: Commonly used in the treatment of peritonitis, cholecystitis, and other intra-abdominal infections.

4. Gynecological Infections

   • Usage: Indicated for infections such as endometritis and pelvic inflammatory disease.

5. Urinary Tract Infections

   • Usage: Treats complicated and uncomplicated urinary tract infections (UTIs) caused by susceptible bacteria.

6. Bacterial Septicemia

   • Usage: Employed in the treatment of bacterial septicemia, a serious bloodstream infection.

7. Bone and Joint Infections

   • Usage: Effective for treating osteomyelitis and septic arthritis caused by susceptible organisms.

8. Meningitis

   • Usage: Used in the treatment of bacterial meningitis.

Mechanism of Action

• Ampicillin: A beta-lactam antibiotic that inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), leading to cell lysis and death.
• Sulbactam: A beta-lactamase inhibitor that protects ampicillin from degradation by beta-lactamase enzymes produced by resistant bacteria, thereby extending its spectrum of activity.

Dosage and Administration

• Dosage: The typical dosage for adults varies depending on the severity of the infection. Commonly, 1.5 to 3 grams (ampicillin 1g + sulbactam 0.5g to ampicillin 2g + sulbactam 1g) is administered every 6 hours.
• Route: Can be administered either intravenously (IV) or intramuscularly (IM).
• Duration: Treatment duration depends on the type and severity of the infection, as well as patient response.

Precautions and Contraindications

• Allergies: Contraindicated in patients with a known allergy to penicillins or beta-lactam antibiotics.
• Renal Impairment: Dosage adjustment may be necessary in patients with impaired renal function.
• Liver Function: Use with caution in patients with hepatic dysfunction.

Side Effects

Common side effects include:

• Gastrointestinal disturbances (nausea, vomiting, diarrhea)
• Rash and hypersensitivity reactions
• Pain at the injection site

Serious side effects, though rare, may include:

• Anaphylaxis and severe allergic reactions
• Clostridium difficile-associated diarrhea
• Hepatic dysfunction and jaundice