Co Amoxiclav (Gomox 457) 457mg/5ml Powder for Suspension 70ml

Here’s the detailed information for Co-Amoxiclav (Gomox 457) 457mg/5ml Powder for Suspension 70ml:

Product Description:

Co-Amoxiclav (Gomox 457) is an antibiotic suspension that combines Amoxicillin and Clavulanic Acid in a ratio of 457mg of Amoxicillin and 5mg of Clavulanic Acid per 5ml of the suspension. It comes in a 70ml bottle and is formulated to treat bacterial infections in both children and adults.

• Amoxicillin is a penicillin-class antibiotic that works by inhibiting the growth of bacteria.

• Clavulanic Acid is a β-lactamase inhibitor, which prevents bacteria from breaking down Amoxicillin, enhancing its effectiveness against resistant strains of bacteria.

This combination helps treat a wide range of infections caused by susceptible bacteria.

Indications:

Co-Amoxiclav (Gomox 457) is indicated for the treatment of infections caused by bacteria that are susceptible to the combined action of Amoxicillin and Clavulanic Acid. These include:

1. Respiratory Infections:

   • Pneumonia

   • Acute bronchitis

   • Chronic obstructive pulmonary disease (COPD) exacerbations

   • Sinusitis

   • Pharyngitis (throat infection)

2. Ear Infections:

   • Otitis media (middle ear infection)

3. Urinary Tract Infections:

   • Cystitis (bladder infection)

   • Pyelonephritis (kidney infection)

4. Skin and Soft Tissue Infections:

   • Cellulitis

   • Abscesses

   • Wounds

5. Dental Infections:

   • Periodontal abscess

   • Dental abscesses (with or without pus)

6. Gastrointestinal Infections:

   • Intra-abdominal infections like peritonitis and abscesses

7. Other Infections:

   • Bacterial infections of the bones and joints (e.g., osteomyelitis)

   • Endocarditis (heart valve infections)

Dosage and Administration:

The recommended dosage of Co-Amoxiclav (Gomox 457) varies depending on the age, weight, and severity of the infection. It is important to follow the dosing instructions provided by the healthcare provider. Below are general guidelines for dosing.

Adults and Children Over 12 Years:

• Typical Dose: 10ml (914mg/10ml) of the suspension every 8 hours.

• Severe Infections: The dose may be increased based on the physician's recommendation.

Children (Under 12 Years):

• Infants 3 months and older or children: The dosage is based on the child's weight:

  • 25-50mg/kg/day divided into 3 doses (every 8 hours).

  • The suspension can be given using a measuring spoon or syringe for accurate dosing.

Note: Always shake the bottle well before use and ensure you use the provided measuring device to ensure accurate dosing.

Side Effects:

As with any medication, Co-Amoxiclav (Gomox 457) can cause side effects, although not everyone will experience them. Common and serious side effects include:

Common Side Effects:

• Gastrointestinal disturbances such as:

  • Nausea

  • Vomiting

  • Diarrhea

  • Indigestion

• Skin Reactions:

  • Rashes or itching

Less Common but Serious Side Effects:

• Liver Issues:

  • Hepatitis (inflammation of the liver) or jaundice (yellowing of the skin or eyes)

• Allergic Reactions:

  • Anaphylaxis (severe allergic reaction causing difficulty breathing, swelling of the face, and throat)

  • Severe skin reactions (e.g., blistering or peeling of the skin, redness, swelling)

• Blood Disorders:

  • Leukopenia (low white blood cell count)

  • Thrombocytopenia (low platelet count)

  • Anemia (low red blood cell count)

• Kidney Problems:

  • Renal impairment (problems with kidney function)

• Superinfection:

  • Prolonged use of antibiotics like Co-Amoxiclav can lead to overgrowth of non-susceptible organisms, such as fungal infections.

Contraindications:

Co-Amoxiclav (Gomox 457) is contraindicated in the following cases:

1. Hypersensitivity to Amoxicillin, Clavulanic Acid, or Penicillin-Class Antibiotics:

   • Individuals with a known allergy to Amoxicillin, Clavulanic Acid, or other penicillin-based antibiotics should avoid this medication due to the risk of severe allergic reactions.

2. History of Liver Dysfunction:

   • Patients who have experienced jaundice or liver dysfunction while taking Co-Amoxiclav or other penicillin antibiotics should not use this medication.

3. Mononucleosis (Infectious Mononucleosis):

   • Use of Co-Amoxiclav is not recommended in patients with mononucleosis due to an increased risk of developing rash.

4. Severe Renal Impairment:

   • Patients with severe kidney impairment (e.g., creatinine clearance less than 30ml/min) may require dose adjustments and should use the medication cautiously.

5. Penicillin Hypersensitivity:

   • Individuals with a history of severe allergic reactions (e.g., anaphylaxis) to penicillin antibiotics should not use Co-Amoxiclav.

Precautions:

• Monitor Liver Function:

  • It is important to monitor liver function regularly in patients who are receiving long-term treatment with Co-Amoxiclav.

• GI Issues:

  • If diarrhea occurs, especially severe or persistent diarrhea, it may be a sign of Clostridium difficile-associated diarrhea (CDAD), which requires prompt medical attention.

• Renal Function:

  • If you have kidney problems or are on dialysis, dosing adjustments may be necessary. Consult your healthcare provider before use.

• Pregnancy and Breastfeeding:

  • Co-Amoxiclav is generally considered safe for use during pregnancy and breastfeeding. However, it should be taken under medical supervision.

• Superinfection Risk:

  • Prolonged use of Co-Amoxiclav may lead to overgrowth of non-susceptible organisms, which could require discontinuation of therapy.

Summary:

Co-Amoxiclav (Gomox 457) is an antibiotic suspension combining Amoxicillin (457mg/5ml) and Clavulanic Acid (5mg/5ml). It is used to treat a wide range of bacterial infections, including respiratory, ear, urinary, skin, and gastrointestinal infections.

• Dosage: Typically 10ml (914mg/10ml) every 8 hours for adults, with pediatric doses based on weight.

• Side Effects: Common side effects include gastrointestinal discomfort (nausea, diarrhea), and rare but serious effects include liver problems, allergic reactions, and blood disorders.

• Contraindications: Not suitable for those with a penicillin allergy, liver dysfunction, or mononucleosis.

Always consult a healthcare provider for personalized advice and appropriate monitoring during treatment.