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Dexamethasone (Impodex) 500mcg Tablet Corticosteroid 100's
Dexamethasone (Impodex) 500mcg Tablet Corticosteroid 100's
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Certainly! Here’s the detailed information for Dexamethasone (Impodex) 500mcg Tablet, Corticosteroid (100’s):
Product Description:
Impodex contains Dexamethasone, a synthetic corticosteroid with potent anti-inflammatory and immunosuppressive properties. The active ingredient, Dexamethasone, works by suppressing the immune system and reducing inflammation in the body. It is used to treat a variety of conditions related to inflammation and immune system disorders.
Each tablet contains 500 micrograms (mcg) of Dexamethasone. The pack contains 100 tablets.
Dexamethasone is widely used for its ability to treat conditions like allergies, inflammatory disorders, and autoimmune diseases. As a corticosteroid, it helps to suppress inflammation by inhibiting the action of substances in the body that cause inflammation and immune responses.
Indications:
Dexamethasone (Impodex) is used for a variety of medical conditions, including but not limited to:
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Anti-inflammatory Treatment:
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Conditions such as rheumatoid arthritis, osteoarthritis, bursitis, tendonitis, and systemic lupus erythematosus.
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Treatment of inflammatory eye conditions (e.g., uveitis) and skin disorders like eczema or dermatitis.
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Autoimmune Diseases:
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Used to treat autoimmune disorders such as multiple sclerosis, myasthenia gravis, and pemphigus vulgaris.
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Allergic Reactions:
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Severe allergic conditions, including anaphylaxis or severe asthma.
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Endocrine Disorders:
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Used in the management of adrenal insufficiency (Addison’s disease) or other conditions causing adrenal hormone deficiencies.
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Cancer Treatment:
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Dexamethasone is sometimes used to reduce inflammation and manage symptoms in cancer patients, such as reducing swelling in the brain or alleviating nausea caused by chemotherapy.
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Respiratory Conditions:
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In the treatment of severe asthma, COPD (Chronic Obstructive Pulmonary Disease) exacerbations, and respiratory distress.
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Edema:
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Management of cerebral edema (swelling of the brain) or spinal cord edema due to trauma or tumors.
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Dosages:
The dosage of Dexamethasone (Impodex) depends on the specific condition being treated, the severity of the condition, and the patient's response to therapy. It is typically initiated at a higher dose and tapered down over time.
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For Adults:
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Initial Dose: For many conditions, the typical initial dose ranges from 0.75 to 9 mg daily, depending on the severity of the condition. For example, for inflammation, a starting dose could be 4-6 mg/day.
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Maintenance Dose: The maintenance dose is usually 0.75-1.5 mg per day, depending on the response and tolerance.
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For Inflammatory Conditions:
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Rheumatoid arthritis or osteoarthritis: Initial doses might range from 0.5-9 mg/day, and the dosage is adjusted based on the response.
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For Allergic Reactions:
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Severe allergic reactions: The initial dose may vary but typically starts with 4-6 mg once or twice daily, with adjustments based on the response.
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For Severe Asthma or Respiratory Issues:
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The dose for asthma exacerbations may start at 4-12 mg/day, depending on the severity.
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For Adrenal Insufficiency (Addison's Disease):
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Usually requires 0.75 to 9 mg/day.
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For Short-term Use (e.g., in emergencies or post-surgery):
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The dosage may start high (e.g., 4-12 mg/day) and then gradually taper based on clinical response and improvement.
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Note: Dexamethasone should always be prescribed and adjusted by a healthcare provider, and dosage should never be altered without professional guidance.
Side Effects:
Like all medications, Dexamethasone (Impodex) can cause side effects, especially when used long-term or at high doses. These may include:
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Common Side Effects:
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Increased appetite and potential weight gain.
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Fluid retention leading to swelling, particularly in the legs and ankles.
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Indigestion, nausea, or gastritis.
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Mood changes: Irritability, anxiety, or mood swings.
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Trouble sleeping (insomnia).
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Increased blood sugar levels, which may be a concern for diabetic patients.
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Serious Side Effects:
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Osteoporosis (bone thinning), particularly with long-term use, increasing the risk of fractures.
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Cataracts and glaucoma, especially with prolonged use.
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High blood pressure (hypertension) due to fluid retention and changes in electrolyte balance.
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Increased risk of infections due to immune suppression.
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Peptic ulcers and gastrointestinal bleeding.
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Adrenal suppression: Long-term use may lead to the body's inability to produce enough natural corticosteroids.
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Psychiatric effects: Severe mood changes, depression, or psychosis.
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Hyperkalemia: Elevated potassium levels leading to muscle weakness, fatigue, or heart problems.
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Cushing's Syndrome: A set of symptoms resulting from prolonged exposure to high doses of corticosteroids, such as moon face, buffalo hump, and central obesity.
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Rare but Severe Side Effects:
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Severe allergic reactions (anaphylaxis): Rash, itching, difficulty breathing, swelling of the face, or throat.
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Myopathy: Muscle weakness, especially in the lower limbs.
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Contraindications:
Dexamethasone (Impodex) should not be used in the following situations:
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Hypersensitivity:
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Contraindicated in patients with a known allergy to dexamethasone or other corticosteroids.
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Systemic Fungal Infections:
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Should not be used in patients with systemic fungal infections (such as histoplasmosis, coccidioidomycosis, or candidiasis).
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Active or History of Peptic Ulcer Disease:
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Caution is required in patients with a history of gastric ulcers, as dexamethasone can exacerbate this condition.
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Severe Cardiovascular Disease:
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Dexamethasone should be used with caution in patients with severe cardiovascular diseases such as heart failure, as it can exacerbate fluid retention and raise blood pressure.
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Psychiatric Disorders:
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Caution is required in patients with severe psychiatric conditions, such as schizophrenia or bipolar disorder, as corticosteroids can exacerbate mood swings and psychosis.
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Infections:
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Dexamethasone can suppress the immune response, and caution is needed if there are active infections (e.g., tuberculosis, viral infections, or fungal infections). It may mask signs of infection or worsen existing infections.
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Diabetes:
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In diabetic patients, dexamethasone can increase blood sugar levels, so close monitoring is essential. It may be contraindicated or require dose adjustment in patients with poorly controlled diabetes.
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Severe Renal or Hepatic Disease:
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Dexamethasone should be used cautiously in patients with severe renal or hepatic impairment, as it may accumulate in the body and increase the risk of side effects.
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Warnings and Precautions:
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Gradual Tapering:
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Long-term use of dexamethasone can suppress the body's natural production of cortisol. Tapering the dose gradually is crucial when discontinuing the medication to allow the adrenal glands to resume normal function.
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Bone Health:
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Prolonged use may cause osteoporosis. Patients should be monitored for bone health, and preventive measures like calcium and vitamin D supplementation may be recommended.
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Vaccinations:
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Live vaccines should be avoided during treatment with corticosteroids due to the risk of infections.
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Vaccinations should be up-to-date before starting dexamethasone treatment.
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Blood Sugar Levels:
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Dexamethasone can increase blood sugar levels, so patients with diabetes need close monitoring and potential adjustments in their diabetic medications.
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Eye Health:
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Prolonged use can increase the risk of glaucoma and cataracts. Regular eye exams are recommended.
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Infection Risk:
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As dexamethasone suppresses the immune system, it increases the risk of infections. Signs of infections should be monitored, and prompt medical attention is needed if symptoms arise.
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Storage:
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Store Dexamethasone (Impodex) at room temperature (between 20°C to 25°C), away from moisture and light.
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Keep out of reach of children.
Important Note: Dexamethasone (Impodex) should always be used according to your healthcare provider's instructions. It is a powerful medication with potential side effects, especially with long-term use, so regular follow-ups are important to monitor for any adverse reactions or complications.
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