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Epinephrine 1mg / ml IM/ IV/ SC (Grandpharma) Ampoules 10's
Epinephrine 1mg / ml IM/ IV/ SC (Grandpharma) Ampoules 10's
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Here’s a detailed overview of Epinephrine 1mg/ml (Grandpharma) Solution for Injection (IM/IV/SC) 1ml x Ampoules 10's:
Product Description:
Epinephrine 1mg/ml (Grandpharma) is a solution for injection that contains epinephrine (also known as adrenaline) as the active ingredient. Epinephrine is a naturally occurring hormone produced by the adrenal glands, which plays an essential role in the body’s fight-or-flight response. It is a sympathomimetic drug that acts on alpha and beta-adrenergic receptors to exert a variety of physiological effects.
This formulation is available in 1ml ampoules, with each ampoule containing 1mg of epinephrine per ml. It is typically used in emergency medical situations to treat conditions such as anaphylaxis, cardiac arrest, and severe asthma attacks, among others. The ampoules are designed for intramuscular (IM), intravenous (IV), or subcutaneous (SC) administration, depending on the clinical scenario.
Indications:
Epinephrine 1mg/ml (Grandpharma) is used for the emergency treatment of several severe conditions, including:
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Anaphylaxis:
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First-line treatment for severe allergic reactions (anaphylaxis) due to allergens (e.g., insect stings, food allergies, drug reactions) by rapidly reversing symptoms such as airway constriction, hypotension, and shock.
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Cardiac Arrest:
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Epinephrine is an essential drug for cardiopulmonary resuscitation (CPR) in cases of cardiac arrest, to enhance circulation and improve chances of survival by stimulating the heart.
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Severe Asthma Attacks or Bronchospasm:
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Used to treat severe asthma attacks or bronchospasm unresponsive to standard treatments, as it helps relax airway muscles and opens up the air passages.
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Hypotension or Shock:
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Epinephrine may be used in severe hypotension or shock, particularly in cases where other treatments have been ineffective, to improve blood pressure and perfusion to vital organs.
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Croup (in children):
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In children, it may be used to treat croup, a condition characterized by airway swelling and difficulty breathing.
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Dosages and Administration:
The dosage of Epinephrine 1mg/ml (Grandpharma) depends on the condition being treated and the patient's age. The following are general guidelines:
For Anaphylaxis (Severe Allergic Reaction):
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Adults:
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0.3–0.5 mg (IM or SC) every 5–10 minutes as needed until symptoms resolve.
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Children:
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0.01 mg/kg of body weight (IM or SC) up to a maximum of 0.3 mg per dose, repeated every 5–10 minutes if necessary.
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For Cardiac Arrest:
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Adults:
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1 mg IV every 3–5 minutes during cardiac arrest until return of spontaneous circulation or advanced cardiac life support is provided.
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For Severe Asthma or Bronchospasm:
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Adults and Children:
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0.3–0.5 mg IM as a one-time dose, repeatable every 20 minutes if necessary, especially in severe cases that are unresponsive to other bronchodilators.
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For Hypotension or Shock:
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Adults:
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IV infusion of 0.1–0.5 mcg/kg/min to restore and maintain blood pressure, titrating based on clinical response.
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For Croup (in children):
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Children:
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0.01 mg/kg (IM or SC) up to a maximum of 0.3 mg.
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Side Effects:
Epinephrine is a potent drug, and although it is often lifesaving, it can lead to a variety of side effects. Common and serious side effects include:
Common Side Effects:
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Tachycardia (increased heart rate)
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Hypertension (high blood pressure)
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Nervousness or anxiety
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Tremors (shaking hands or other parts of the body)
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Dizziness or headache
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Palpitations (sensation of a racing heartbeat)
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Nausea or vomiting
Serious Side Effects (require immediate medical attention):
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Arrhythmias (irregular heart rhythms, including ventricular arrhythmias)
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Myocardial ischemia (reduced blood flow to the heart)
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Pulmonary edema (fluid accumulation in the lungs)
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Severe chest pain (could indicate a heart attack)
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Severe hypertension (which may lead to stroke or organ damage)
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Severe allergic reactions (rare, but can occur in hypersensitive individuals)
Contraindications:
While Epinephrine 1mg/ml (Grandpharma) is effective in many emergency situations, it is contraindicated or should be used with caution in certain conditions:
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Hypersensitivity:
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Epinephrine should not be used in individuals who are allergic or hypersensitive to epinephrine or any other components of the formulation.
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Narrow-Angle Glaucoma:
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Contraindicated in individuals with narrow-angle glaucoma, as epinephrine can increase intraocular pressure.
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Shock due to non-anaphylactic causes:
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Should be used with caution in cases of non-anaphylactic shock, as it may worsen these conditions.
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Severe Hypertension:
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Contraindicated in patients with severe hypertension, as epinephrine can increase blood pressure and further exacerbate this condition.
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Coronary Artery Disease:
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Use with caution in patients with coronary artery disease, angina, or a history of heart attack due to the risk of increasing myocardial oxygen demand and potentially triggering a heart attack.
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Hyperthyroidism:
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Epinephrine should be used cautiously in individuals with hyperthyroidism, as it can exacerbate symptoms like tachycardia and arrhythmias.
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Pheochromocytoma:
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Pheochromocytoma (a tumor of the adrenal gland) can cause severe hypertension when treated with epinephrine, and it should be avoided in such patients.
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Pregnancy:
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Category C in pregnancy, meaning it may be used during pregnancy only if the potential benefit justifies the risk to the fetus. It should be avoided in early pregnancy unless absolutely necessary.
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Severe Anxiety or Agitation:
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Use with caution in patients with a history of severe anxiety or agitation, as epinephrine can worsen these symptoms.
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Precautions:
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Careful Monitoring:
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Patients receiving epinephrine should be closely monitored, particularly for blood pressure and heart rate, as hypertension and tachycardia are common side effects.
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Proper Injection Technique:
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Epinephrine should be administered by a healthcare professional trained in emergency procedures to ensure proper technique and avoid complications like incorrect dosage or injection site issues.
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Drug Interactions:
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Epinephrine may interact with several drugs, including beta-blockers, which may reduce its effectiveness in treating conditions like cardiac arrest. Additionally, monoamine oxidase inhibitors (MAOIs) and tricyclic antidepressants (TCAs) can potentiate the hypertensive effects of epinephrine.
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Summary:
Epinephrine 1mg/ml (Grandpharma) is a critical medication used in emergency care for treating anaphylaxis, cardiac arrest, severe asthma, and other life-threatening conditions. By stimulating alpha and beta-adrenergic receptors, it causes vasoconstriction, bronchodilation, and increases heart rate, which helps to reverse dangerous symptoms in critical situations.
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Indications: Anaphylaxis, cardiac arrest, severe asthma, hypotension, croup.
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Dosage: 0.3–0.5 mg IM/SC for anaphylaxis; 1 mg IV for cardiac arrest; dosages for other conditions vary.
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Side Effects: Tachycardia, hypertension, tremors, arrhythmias, and more serious cardiovascular side effects.
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Contraindications: Hypersensitivity, narrow-angle glaucoma, severe hypertension, coronary artery disease, etc.
Always use Epinephrine 1mg/ml (Grandpharma) under medical supervision, especially in critical care settings.
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