Metoprolol Tartate (Prometin) 50mg Tablets 100's

Product Description:

Metoprolol Tartrate (Prometin) is a beta-blocker medication primarily used to treat high blood pressure (hypertension) and other cardiovascular conditions. Each tablet contains 50 mg of Metoprolol Tartrate, which works by blocking the effects of adrenaline (epinephrine) on the beta receptors in the heart, blood vessels, and other tissues. This leads to a decrease in heart rate, blood pressure, and the workload on the heart.

Prometin 50mg Tablets come in 100-tablet bottles, providing a cost-effective solution for long-term management of heart conditions, especially when daily medication is required.

Indications:

Metoprolol Tartrate (Prometin) is used for the following indications:

1. Hypertension (High Blood Pressure):

   • Metoprolol helps lower blood pressure by reducing heart rate and the force of contraction, thus easing the burden on the heart and reducing the risk of heart disease.

2. Angina Pectoris (Chest Pain):

   • By decreasing the heart's workload, Metoprolol is used to prevent and manage angina (chest pain), which is often caused by narrowed coronary arteries.

3. Acute Myocardial Infarction (Heart Attack):

   • Metoprolol may be used to reduce mortality following an acute heart attack by protecting the heart and reducing its oxygen demand.

4. Heart Failure:

   • It can be used in the treatment of chronic heart failure, helping to improve symptoms and reduce hospitalizations due to its effects on heart rate and blood pressure.

5. Arrhythmias (Irregular Heartbeats):

   • It is used to manage various arrhythmias, such as atrial fibrillation, by controlling the heart rate.

Dosage:

The recommended dosage of Metoprolol Tartrate (Prometin) will vary depending on the condition being treated, but the following are general guidelines:

For Hypertension:

• Initial Dose: 50 mg once daily, either as a single dose or divided into two doses.

• Maintenance Dose: The dose may be increased depending on the response, up to 100 mg daily.

• For some patients, the dose may be titrated higher, but this should be done under the guidance of a healthcare provider.

For Angina Pectoris:

• Initial Dose: 50 mg twice daily.

• Maintenance Dose: The dose may be adjusted based on the patient's condition, typically ranging from 100 mg to 200 mg daily.

For Acute Myocardial Infarction (Heart Attack):

• Initial Dose: Typically given as an intravenous (IV) injection during an acute phase, followed by 50 mg orally twice daily after the patient is stable.

For Heart Failure:

• Starting Dose: A lower starting dose of 12.5 mg to 25 mg daily is often used in heart failure, gradually increasing the dose depending on the patient's tolerance and response.

For Arrhythmias:

• Initial Dose: 50 mg twice daily, with adjustments based on heart rate and rhythm.

Administration:

• The tablets should be taken with or without food. It's typically recommended to take them at the same time every day.

• Dosage adjustments are often required based on the patient's response to treatment.

Side Effects:

While Metoprolol Tartrate (Prometin) is generally well tolerated, some people may experience side effects, including:

Common Side Effects:

• Fatigue.

• Dizziness or lightheadedness.

• Bradycardia (slow heart rate).

• Nausea or vomiting.

• Cold hands or feet.

• Hypotension (low blood pressure).

Serious Side Effects (rare, but may occur):

• Severe Bradycardia (extremely slow heart rate) – may require dose adjustment.

• Heart failure symptoms worsening – such as shortness of breath, swelling of the feet or ankles.

• Severe dizziness or fainting.

• Shortness of breath, especially during physical activity.

• Severe allergic reactions: Symptoms of an allergic reaction may include rash, itching, swelling, or difficulty breathing.

• Liver dysfunction (rare): Symptoms may include yellowing of the skin or eyes, dark urine, or stomach pain.

If any of these serious side effects occur, immediate medical attention is needed.

Contraindications:

Metoprolol Tartrate (Prometin) should be avoided or used with caution in the following situations:

1. Hypersensitivity: Known allergy to Metoprolol or any of the ingredients in the formulation.

2. Severe Bradycardia (slow heart rate): Metoprolol can further lower the heart rate, so it is contraindicated in patients with heart rate less than 45 beats per minute.

3. Heart Block (2nd or 3rd degree): Patients with significant atrioventricular (AV) block should avoid Metoprolol as it can worsen the condition.

4. Severe Heart Failure: Although used in the management of heart failure, Metoprolol should be used cautiously in decompensated heart failure or when the patient’s condition is unstable.

5. Asthma or Chronic Obstructive Pulmonary Disease (COPD): Metoprolol should be avoided in patients with asthma or severe COPD, as beta-blockers can potentially cause bronchoconstriction, leading to breathing difficulties.

6. Severe Liver Impairment: Metoprolol is metabolized in the liver, so patients with severe hepatic dysfunction may need a lower dose or an alternative medication.

7. Severe Hypotension (Low Blood Pressure): Caution should be used in patients with significantly low blood pressure.

8. Pheochromocytoma: Metoprolol should not be used alone in the treatment of patients with pheochromocytoma (a tumor of the adrenal glands) without prior alpha-blocker treatment, as it can cause a hypertensive crisis.

Precautions:

• Pregnancy: Metoprolol is classified as Category C in pregnancy, meaning it should only be used if the benefits outweigh the risks. It may affect fetal circulation and heart rate.

• Breastfeeding: Metoprolol is excreted in breast milk, so it should be used cautiously or avoided during breastfeeding unless absolutely necessary.

• Renal and Hepatic Impairment: In patients with kidney or liver disease, the dose may need to be adjusted. Regular monitoring is essential.

• Diabetes: Metoprolol can mask some of the symptoms of low blood sugar (hypoglycemia), such as tachycardia, in people with diabetes. Patients should monitor their blood sugar closely.

• Discontinuation: Abrupt cessation of Metoprolol can lead to rebound hypertension or worsening angina. It should be tapered off gradually under a healthcare provider's supervision.

Drug Interactions:

• Calcium Channel Blockers (such as Verapamil or Diltiazem): Concomitant use with Metoprolol may increase the risk of severe bradycardia and heart block.

• Clonidine: Abrupt discontinuation of Clonidine after using Metoprolol may cause a hypertensive crisis.

• Digoxin: Use of Metoprolol with Digoxin may increase the risk of bradycardia.

• NSAIDs: Nonsteroidal anti-inflammatory drugs (NSAIDs) may reduce the effectiveness of Metoprolol in lowering blood pressure.

• Insulin and Oral Hypoglycemic Agents: As mentioned earlier, Metoprolol can mask symptoms of hypoglycemia, so careful monitoring is required for patients using insulin or diabetic medication.

Conclusion:

Metoprolol Tartrate (Prometin) 50mg Tablets are an effective medication for managing hypertension, angina, heart failure, and arrhythmias. While generally safe, it's essential to follow dosing instructions carefully and consult a healthcare provider before starting treatment, especially if you have underlying medical conditions such as asthma, liver disease, or heart block. Be aware of potential side effects and drug interactions, and report any unusual symptoms to your doctor.