Montelukast + Levocetirizine Dihydrochloride 10mg/5ml Film Coated Tablet 30's

Generic Name: MONTELUKAST + LEVOCETIRIZINE DIHYDROCHLORIDE

Brand Name: LEVOSAPHZINE-PLUS

Strength: 10mg / 5mg

Form: FC TABLET

Manufacturer: SAPPHIRE LIFESCIENCES PVT. LTD. 

Imported and Distributed by: NELPHA LIFESCIENCES, INC.

Classification: LEUKOTRIENE RECEPTOR ANTAGONIST-ANTIHISTAMINE COMBINATION

Indication/Uses: 

Indications:

1. Allergic Rhinitis:

   • Montelukast and Levocetirizine combination is indicated for the relief of symptoms of seasonal allergic rhinitis (SAR) and perennial allergic rhinitis (PAR). These symptoms include sneezing, rhinorrhea (runny nose), nasal congestion, and itchy eyes.

2. Chronic Urticaria:

   • The combination is used to treat chronic urticaria (hives), providing relief from itching and reducing the severity and number of hives.

3. Asthma:

   • Montelukast, one of the components, is a leukotriene receptor antagonist used for the prevention and long-term treatment of asthma. It helps in preventing bronchospasm and reducing asthma symptoms.

Uses:

1. Symptomatic Relief:

   • Provides relief from allergic symptoms such as sneezing, runny or itchy nose, and watery eyes. Levocetirizine is an antihistamine that reduces the effects of natural histamine in the body, which can produce allergy symptoms.

2. Anti-Inflammatory Effects:

   • Montelukast helps to reduce inflammation in the airways, making it easier to breathe and preventing asthma attacks.

3. Combination Therapy Benefits:

   • The combination of montelukast and levocetirizine provides both immediate relief of allergy symptoms through the antihistamine action of levocetirizine and long-term management of asthma and allergic inflammation through the leukotriene receptor antagonist action of montelukast.

Mechanism of Action:

• Montelukast: Works by blocking leukotrienes, substances in the body that cause the symptoms of asthma and allergic rhinitis. By inhibiting leukotriene receptors, montelukast prevents airway edema, smooth muscle contraction, and other respiratory inflammation.

• Levocetirizine: Acts as a selective histamine H1 receptor antagonist, reducing histamine-mediated symptoms such as nasal congestion, sneezing, and itching.

Dosage and Administration:

• Typically taken once daily in the evening, with or without food.
• The dosage should be followed as prescribed by a healthcare provider.