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Bambang Pharmaceutical Depot Inc.

Pantoprazole Domperidone (Cytoran Plus) 40mg/30mg Modified Release Capsule 30's

Pantoprazole Domperidone (Cytoran Plus) 40mg/30mg Modified Release Capsule 30's

Regular price ₱470.00
Regular price ₱940.00 Sale price ₱470.00
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Proton Pump Inhibitor / Gastrokinetic

Product Description:

Pantoprazole Domperidone (Cytoran Plus) 40mg/30mg Modified Release Capsules is a combination medication used primarily for the treatment of gastrointestinal disorders. It combines Pantoprazole, a proton pump inhibitor (PPI), with Domperidone, a dopamine antagonist that helps with gastrointestinal motility. This combination works together to relieve symptoms of acid-related stomach problems and improve digestion by increasing the movement of the stomach and intestines.

  • Pantoprazole (40mg): Inhibits gastric acid production, reducing the amount of acid in the stomach and helping heal stomach ulcers or prevent acid reflux.

  • Domperidone (30mg): Acts as a prokinetic agent, helping to promote the movement of food through the stomach and intestines, improving symptoms like nausea and bloating.

The modified-release formulation of this combination ensures the gradual release of the active ingredients over time for prolonged therapeutic effects.

Each pack contains 30 capsules of Pantoprazole 40mg / Domperidone 30mg.

Indications:

Pantoprazole Domperidone (Cytoran Plus) 40mg/30mg Modified Release Capsule is indicated for the treatment of the following conditions:

  1. Gastroesophageal Reflux Disease (GERD): To manage acid reflux and related symptoms such as heartburn and regurgitation.

  2. Peptic Ulcers: For the healing of stomach ulcers and prevention of recurrence.

  3. Dyspepsia (Indigestion): To relieve symptoms such as nausea, bloating, and discomfort in the upper abdomen.

  4. Gastroparesis: To improve the motility of the stomach and reduce delayed gastric emptying in conditions like diabetic gastroparesis.

  5. Nausea and Vomiting: Associated with various gastrointestinal conditions, including functional dyspepsia.

Dosage and Administration:

  • Recommended Dosage:

    • Adults: Take one capsule of Pantoprazole Domperidone (Cytoran Plus) 40mg/30mg once daily, preferably in the morning, before meals. This medication is meant to be taken as a single dose per day, as per the doctor’s instructions.

    • The capsule should be swallowed whole and should not be chewed or crushed. It is important to take the medication as prescribed by your healthcare provider to achieve the best results.

  • Duration of Treatment: The duration of therapy depends on the condition being treated. For conditions like GERD or peptic ulcers, it can range from a few weeks to several months. For gastroparesis, the treatment duration may be longer.

  • Use in Children: This medication is typically not recommended for children unless specifically prescribed by a healthcare provider.

Side Effects:

While Pantoprazole Domperidone (Cytoran Plus) is generally well-tolerated, some side effects may occur, including:

  1. Common Side Effects:

    • Headache

    • Dizziness

    • Nausea or vomiting

    • Dry mouth

    • Abdominal discomfort or bloating

    • Diarrhea or constipation

    • Fatigue or feeling tired

  2. Serious Side Effects (rare, but require immediate medical attention):

    • Severe allergic reactions: Swelling of the face, lips, throat, or tongue, difficulty breathing (anaphylaxis).

    • Severe skin reactions: Rash, itching, or blistering skin.

    • Heart problems: Fast or irregular heartbeat, palpitations.

    • Liver damage: Yellowing of the skin or eyes (jaundice), dark urine.

    • Movement disorders: Uncontrollable muscle movements, tremors, stiffness.

    • Low magnesium levels: Muscle spasms, dizziness, irregular heartbeat.

Contraindications:

Pantoprazole Domperidone (Cytoran Plus) 40mg/30mg should not be used in the following cases:

  1. Hypersensitivity to Pantoprazole, Domperidone, or any component of the formulation.

  2. Severe Liver Impairment: Individuals with liver disease (such as cirrhosis) should avoid using this medication due to the potential for severe drug interactions and altered metabolism.

  3. Prolonged QT Interval: Domperidone can prolong the QT interval, a condition that affects the heart’s electrical activity. This medication should not be used in patients with a known history of QT prolongation, heart arrhythmias, or other heart conditions.

  4. Severe Renal Impairment: Caution is advised in individuals with kidney disease, and dose adjustments may be required.

  5. Gastrointestinal Bleeding or Obstruction: The use of this medication is contraindicated in cases of gastrointestinal bleeding, obstruction, or perforation.

  6. Pregnancy and Breastfeeding: While Pantoprazole is considered relatively safe in pregnancy (Category B), Domperidone should be avoided during pregnancy and breastfeeding due to potential risks to the fetus or infant.

Warnings and Precautions:

  • Electrolyte Imbalance: Prolonged use of Pantoprazole can lead to reduced magnesium levels, which may increase the risk of side effects such as muscle cramps or heart arrhythmias. Regular monitoring of magnesium levels may be required.

  • Drug Interactions: Pantoprazole may interact with certain medications, including warfarin, clopidogrel, and certain antifungals. Domperidone can interact with medications that affect heart rhythm, such as antiarrhythmics and certain antidepressants.

  • Caution in Elderly: Elderly individuals may be more sensitive to the side effects, particularly with regards to heart issues.

  • Prolonged Treatment: Prolonged use of Pantoprazole may lead to an increased risk of certain conditions, including vitamin B12 deficiency, bone fractures, and Clostridium difficile infections.

  • Kidney and Liver Function: Caution is recommended for patients with existing kidney or liver issues. The medication should be used with care in such patients, and dose adjustments may be required.

Storage:

  • Store at room temperature (15°C to 30°C / 59°F to 86°F) in a cool, dry place.

  • Keep the medication in its original packaging and away from moisture.

  • Keep out of reach of children.

Conclusion:

Pantoprazole Domperidone (Cytoran Plus) 40mg/30mg Modified Release Capsules is a dual-action medication effective in treating conditions related to acid reflux, peptic ulcers, and gastrointestinal motility disorders. It works by reducing stomach acid production (Pantoprazole) and improving gastrointestinal motility (Domperidone). While effective, it is important to use this medication according to your healthcare provider's instructions, and to be aware of potential side effects and contraindications. Regular monitoring may be necessary for long-term users. Always consult with a healthcare provider before starting this medication.

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