Piperacillin + Tazobactam (Pipetollen) 2g/250mg Powder For Injection (I.V Infusion) Vial 1's

Generic Name: Piperacillin + Tazobactam

Brand Name: Pipetollen

Strength: 2g / 250mg

Form: Vial

Manufacturer:

Imported and Distributed by:

Classification: Antibacterial

Indication/Uses:

Piperacillin + Tazobactam, marketed as Pipetollen 2g/250mg, is a combination antibiotic available as a powder for intravenous (IV) infusion. This formulation contains 2 grams of piperacillin and 250 milligrams of tazobactam. Here are the main indications and uses:

Indications and Uses

1. Complicated Intra-Abdominal Infections:

   • Infections: Effective for treating complicated intra-abdominal infections such as peritonitis or intra-abdominal abscesses, which often involve a mix of aerobic and anaerobic bacteria.

2. Complicated Skin and Soft Tissue Infections:

   • Infections: Used for severe skin and soft tissue infections, including diabetic foot infections and wound infections where mixed bacterial flora are present.

3. Complicated Urinary Tract Infections (UTIs):

   • Infections: Suitable for treating complicated UTIs, particularly those caused by resistant or multidrug-resistant bacteria.

4. Complicated Pneumonia:

   • Infections: Used in the treatment of complicated pneumonia, including hospital-acquired pneumonia, when caused by susceptible bacteria.

5. Febrile Neutropenia:

   • Infections: Often used for febrile neutropenia (fever in patients with low white blood cell counts), especially in cancer patients undergoing chemotherapy.

6. Sepsis:

   • Infections: Can be used in the treatment of sepsis caused by susceptible organisms.

Mechanism of Action

• Piperacillin: A broad-spectrum penicillin antibiotic that inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), leading to bacterial cell death.
• Tazobactam: A β-lactamase inhibitor that protects piperacillin from degradation by β-lactamase enzymes produced by some bacteria, thus extending the spectrum of activity of piperacillin.

Dosage and Administration

• Typical Dosage: The usual dosage is 3.375g to 4.5g administered every 6 to 8 hours, depending on the severity of the infection and the patient’s renal function. The exact dosage may vary based on the infection being treated and individual patient factors.
• Administration: The powder should be reconstituted with a suitable diluent and administered via IV infusion over a period of 30 minutes to 1 hour.

Precautions

• Allergic Reactions: Caution is required in patients with a history of hypersensitivity to penicillins or β-lactam antibiotics.
• Renal Function: Dosage adjustments may be needed for patients with renal impairment as the drug is primarily excreted through the kidneys.
• Superinfection: Prolonged use may lead to superinfections, such as fungal infections, due to disruption of normal flora.

Monitoring

• Renal Function: Regular monitoring of renal function is important, especially in patients with pre-existing renal conditions.
• Therapeutic Response: Assess clinical response to treatment and adjust based on culture results and symptom improvement.

Piperacillin + Tazobactam (Pipetollen 2g/250mg) is a broad-spectrum antibiotic combination used to treat serious infections, particularly those involving multiple types of bacteria. Proper dosing, administration, and monitoring are essential to ensure efficacy and safety.