Generic Name: PROPOFOL

Brand Name: ASPIRO

Strength: 10mg/mL (200mg/20mL)

Form: VIAL

Manufacturer: ASPIRO PHARMA LIMITED 

Imported and Distributed by: CAMBER PHARMACEUTICALS, INC.

Classification: GENERAL ANESTHETIC

Indication/Uses: 

1. Induction of General Anesthesia

   • Usage: Propofol is commonly used to induce general anesthesia in both adult and pediatric patients. It is administered intravenously to achieve a rapid onset of unconsciousness.

2. Maintenance of General Anesthesia

   • Usage: It is also used for the maintenance of anesthesia in conjunction with other anesthetic agents. Propofol allows for the precise control of anesthesia depth during surgical procedures.

3. Sedation for Mechanically Ventilated Patients in Intensive Care Units (ICU)

   • Usage: Propofol is utilized for sedation in adult patients who are mechanically ventilated and require a calm and controlled state for effective ventilation and care.

4. Procedural Sedation

   • Usage: It is used for sedation in diagnostic procedures, such as endoscopies, colonoscopies, and minor surgical interventions. Propofol provides a quick onset and recovery, making it suitable for outpatient procedures.

Mechanism of Action

Propofol works by enhancing the activity of gamma-aminobutyric acid (GABA) at the GABA-A receptors in the brain. This action results in hyperpolarization of neuronal membranes, leading to sedation and hypnosis.

Dosage and Administration

• Induction of Anesthesia:
  • Adults: Typically, 1.5 to 2.5 mg/kg administered intravenously over 20 to 30 seconds.
  • Children: Dosage varies based on age and weight, usually between 2.5 to 3.5 mg/kg.
• Maintenance of Anesthesia:
  • Continuous infusion of 4 to 12 mg/kg/hour or intermittent boluses as required.
• Sedation in ICU:
  • Initial dose of 0.3 to 4.0 mg/kg/hour, adjusted according to patient response.
• Procedural Sedation:
  • Doses vary based on the procedure and patient characteristics, typically starting at 0.5 to 1 mg/kg with incremental doses as needed.