Generic Name: Ranitidine

Brand Name: Raxidine

Strength: 25mg / ml

Form: Ampoule

Manufacturer:

Imported and Distributed by:

Classification: H2-Receptor Antagonist

Indication/Uses:

Ranitidine (Raxidine) 25mg/ml Solution for Injection (I.M/I.V) 2ml x 10 Ampoules is used to manage conditions related to excess stomach acid. Here are the primary indications and uses for this medication:

Indications and Uses

1. Gastric Ulcers:

   • Treatment of Ulcers: Used to treat active gastric ulcers and to help prevent recurrence. It reduces stomach acid production, promoting ulcer healing.

2. Duodenal Ulcers:

   • Treatment and Prevention: Effective in treating duodenal ulcers and in reducing the risk of their recurrence by decreasing stomach acid.

3. Gastroesophageal Reflux Disease (GERD):

   • GERD Management: Helps to manage symptoms of GERD by reducing stomach acid and preventing acid reflux into the esophagus.

4. Zollinger-Ellison Syndrome:

   • Excess Acid Production: Used in the management of Zollinger-Ellison syndrome, a condition characterized by excessive gastric acid production.

5. Preoperative Medication:

   • Acid Reduction: Sometimes administered before surgical procedures to reduce the risk of acid aspiration and related complications.

Mechanism of Action

• H2-Receptor Antagonism: Ranitidine is an H2 receptor antagonist that works by blocking histamine H2 receptors in the stomach lining. This action decreases the production of stomach acid, leading to reduced gastric acidity and relief from acid-related conditions.

Dosage and Administration

• Typical Dosage:
  • Gastric and Duodenal Ulcers: Usually administered as an intravenous injection of 25mg to 50mg every 6 to 8 hours, depending on the severity of the condition and patient response.
  • GERD and Other Conditions: Dosage may vary based on the specific condition and individual patient needs.
• Administration: The solution can be administered intravenously (IV) or intramuscularly (IM). For IV administration, the solution is usually infused slowly to minimize the risk of adverse effects.

Precautions

• Renal Impairment: Use with caution in patients with renal impairment as dosage adjustments may be necessary.
• Allergies: Ensure there are no known allergies to ranitidine or other H2 receptor antagonists.
• Drug Interactions: Be aware of potential drug interactions, especially with medications that are affected by changes in stomach pH.

Side Effects

• Common: Headache, dizziness, constipation, and nausea.
• Serious: Rare but serious side effects may include allergic reactions, liver enzyme changes, and blood disorders such as thrombocytopenia or agranulocytosis.

Monitoring

• Regular Monitoring: Monitor patients for potential side effects, especially if administered for prolonged periods or in high doses.
• Renal Function: Check renal function regularly in patients with compromised kidney function or those on long-term treatment.

Ranitidine (Raxidine) 25mg/ml Solution for Injection is used primarily for managing conditions related to excess stomach acid, including ulcers and GERD. Proper administration, dosage adjustments, and monitoring are essential for effective treatment and minimizing potential side effects.